Cotman, Carl W

Publication Detail

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Visual-discrimination learning ability and beta-amyloid accumulation in the dog.

E Head; H Callahan; B A Muggenburg; C W Cotman; N W Milgram (Profiled Author: Cotman, Carl W)

Institute for Brain Aging and Dementia, University of California, Irvine, 92697-4540, USA. ehead@uci.edu
Neurobiology of aging 1998;19(5):415-25.

Young, middle-aged, and old beagle dogs were tested on several visual-discrimination tasks: reward- and object-approach learning, object discrimination and reversal, long-term retention of a reversal problem, and a size-discrimination task. Beta-amyloid accumulation in the entorhinal, prefrontal, parietal, and occipital cortices was quantified using immunohistochemical and imaging techniques at the conclusion of cognitive testing. Middle-aged and old dogs were impaired in size-discrimination learning. In each task, a subset of aged dogs was impaired relative to age-matched peers. Beta-amyloid accumulation was age-dependent. However, not all middle-aged and old dogs showed beta-amyloid accumulation in the entorhinal cortex. The error scores from dogs tested with a nonpreferred object during visual discrimination learning and from reversal learning were correlated with beta-amyloid in the prefrontal but not entorhinal cortex. Size-discrimination and reward and object-approach learning error scores were correlated with beta-amyloid accumulation in the entorhinal but not prefrontal cortex. The results of these studies support an association between cognitive test and the location and extent of beta-amyloid pathology.

2 Originating Grant

• 1.

  COTMAN, CARL WAYNE

  The Canine as an Animal Model of Human Aging

  30 September 1995 - 31 August 2016

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 3,935,610

• 2.

  Cotman, Carl W

  CANINE AS AN ANIMAL MODEL OF HUMAN AGING

  30 September 1995 - 31 August 2006

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 3,710,320

Scientific Context

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