The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.
Institute for Cancer Research and Treatment, University of Torino, Candiolo, Italy. Itamagnone@ircc.unito.it
In Drosophila, plexin A is a functional receptor for semaphorin-1a. Here we show that the human plexin gene family comprises at least nine members in four subfamilies. Plexin-B1 is a receptor for the transmembrane semaphorin Sema4D (CD100), and plexin-C1 is a receptor for the GPI-anchored semaphorin Sema7A (Sema-K1). Secreted (class 3) semaphorins do not bind directly to plexins, but rather plexins associate with neuropilins, coreceptors for these semaphorins. Plexins are widely expressed: in neurons, the expression of a truncated plexin-A1 protein blocks axon repulsion by Sema3A. The cytoplasmic domain of plexins associates with a tyrosine kinase activity. Plexins may also act as ligands mediating repulsion in epithelial cells in vitro. We conclude that plexins are receptors for multiple (and perhaps all) classes of semaphorins, either alone or in combination with neuropilins, and trigger a novel signal transduction pathway controlling cell repulsion.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
A L Kolodkin; D V Levengood; E G Rowe; Y T Tai; R J Giger; D D GintyCell 1997;90(4):753-62.
R J Giger; J F Cloutier; A Sahay; R K Prinjha; D V Levengood; S E Moore; S Pickering; D Simmons; S Rastan; F S Walsh; et al.Neuron 2000;25(1):29-41.
Chenghua Gu; Yutaka Yoshida; Jean Livet; Dorothy V Reimert; Fanny Mann; Janna Merte; Christopher E Henderson; Thomas M Jessell; Alex L Kolodkin; David D GintyScience (New York, N.Y.) 2005;307(5707):265-8.
Appears in this Publication
Author of this Publication