The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
A novel right-heart catheterization technique for in vivo measurement of vascular responses in lungs of intact mice.
H C Champion; D J Villnave; A Tower; P J Kadowitz; A L Hyman (Profiled Author: Hunter Champion)
Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana, 70112, USA. firstname.lastname@example.org
American journal of physiology. Heart and circulatory physiology 2000;278(1):H8-H15.
The present study employed a new right-heart catheterization technique to measure pulmonary arterial pressure, pulmonary arterial wedge pressure, and pulmonary vascular resistance in anesthetized intact-chest, spontaneously breathing mice. Under fluoroscopic guidance, a specially designed catheter was inserted via the right jugular vein and advanced to the main pulmonary artery. Cardiac output was determined by the thermodilution technique, and measured parameters were stable for periods of </=3 h. Pressure-flow curves in vivo were curvilinear, with mean pulmonary arterial pressure increasing more rapidly at low pulmonary blood flows of 5-10 ml/min and less rapidly at higher blood flow rates. The pressure-flow relationship was shifted to the left by the nitric oxide synthase inhibitor nitro-L-arginine methyl ester (L-NAME) at higher blood flow levels, whereas the cyclooxygenase inhibitor sodium meclofenamate was without effect. The increase in pulmonary arterial pressure in response to acute hypoxia (fractional inspired O(2) 10%) was augmented by L-NAME but unaltered by sodium meclofenamate. The present results demonstrate that the right-heart catheterization technique can be used to measure pulmonary vascular pressures and responses in the mouse. This is, to our knowledge, the first report of a right-heart catheterization technique to measure pulmonary vascular pressures and responses in the intact-chest, spontaneously breathing mouse and should prove useful for the investigation of pulmonary vascular responses in transgenic mice.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
H C Champion; T J Bivalacqua; D G Lambert; R A Abassi; P J KadowitzThe American journal of physiology 1999;277(4 Pt 2):R1179-87.
H C Champion; J A Santiago; M A Czapla; T J Bivalacqua; C Ilgenfritz; P J KadowitzPeptides 1997;18(9):1357-64.
A L Hyman; Q Hao; A Tower; P J Kadowitz; H C Champion; B Gumusel; H LipptonThe American journal of physiology 1998;274(4 Pt 2):H1218-29.
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