Recombination in telomere-length maintenance.

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A Kass-Eisler; C W Greider (Profiled Author: Carol Greider)

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA. kasseisl@cshl.org
Trends in biochemical sciences 2000;25(4):200-4.

PubMed

Abstract

Although telomerase is the major mechanism for telomere elongation in most cells, telomerase-independent mechanisms of telomere maintenance can allow cell survival. Yeast cells that lack telomerase maintain telomere length through a form of recombination known as gene conversion. Understanding the role that telomeric recombination might play in mammalian cells has important implications for cancer therapeutics.

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