The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils.
K K Kikly; B S Bochner; S D Freeman; K B Tan; K T Gallagher; K J D'alessio; S D Holmes; J A Abrahamson; C L Erickson-Miller; P R Murdock; et al. (Profiled Author: Bruce Bochner)
Department of Immunology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA.
The Journal of allergy and clinical immunology 2000;105(6 Pt 1):1093-100.
BACKGROUND: Eosinophils, basophils, and mast cells are believed to be the central tenet cells in allergic conditions including allergic rhinitis, asthma, and eczema. The molecular mechanisms underlying the recruitment of these cells to sites of allergic inflammation are poorly understood. OBJECTIVES: Our aim was to identify a common adhesion molecule that could potentially be responsible for mediating the recruitment of the allergic cell types to the lungs and other sites of allergy. METHODS: We have cloned a sialoadhesin molecule from a human eosinophil library with the use of expressed sequence tag technology and characterized its expression on allergic cells by the use of flow cytometry and specific mAbs. RESULTS: With the use of expressed sequence tag sequencing, we have identified a novel siglec molecule, SAF-2. SAF-2 has homology with other sialoadhesin family members (CD33 and siglec-5) and belongs to a subgroup of the Ig superfamily. SAF-2 is a 431-amino acid protein composed of 3 Ig domains with a 358-amino acid extracellular domain and a 47-amino acid tail. SAF-2 is highly restricted to eosinophils, basophils, and mast cells. Antibodies to SAF-2 do not modulate Ca(++) mobilization or chemotaxis of human eosinophils induced by eotaxin. CONCLUSION: SAF-2 is a highly restricted sialoadhesin molecule, which may be useful in the detection and/or modulation of allergic cells.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Sherry A Hudson; Harald Herrmann; Jian Du; Paul Cox; El-Bdaoui Haddad; Barbara Butler; Paul R Crocker; Steven J Ackerman; Peter Valent; Bruce S BochnerJournal of clinical immunology 2011;31(6):1045-53.
Takumi Kiwamoto; Norihito Kawasaki; James C Paulson; Bruce S BochnerPharmacology & therapeutics 2012;135(3):327-36.
B S BochnerClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2009;39(3):317-24.
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