The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Association of angiotensin-converting enzyme DD genotype with blood pressure sensitivity to weight loss.
John B Kostis; Alan C Wilson; W Craig Hooper; Kathryn W Harrison; Claire S Philipp; Lawrence J Appel; Mark A Espeland; Steven Folmar; Karen C Johnson; (Profiled Author: Lawrence Appel)
UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ 08903-0019, USA. firstname.lastname@example.org
American heart journal 2002;144(4):625-9.
BACKGROUND: Weight loss and sodium reduction are useful nonpharmacologic interventions in the management of hypertension. Salt sensitivity--the degree of blood pressure change in response to a change in sodium load--has been extensively explored. However, the determinants of the extent of blood pressure change after weight reduction have not been evaluated. METHODS: We studied the relationship of the angiotensin-converting enzyme insertion-deletion (ACE I/D) polymorphism to blood pressure change after weight loss in the Trial Of Nonpharmacologic interventions in the Elderly (TONE). We focused on the 86 overweight white hypertensive TONE participants who were randomized to weight loss only. RESULTS: A similar weight reduction was observed across all ACE genotypes, whereas a significantly greater decrease in blood pressure after weight loss was seen among participants with the DD genotype. In addition, DD participants had a higher probability of remaining normotensive for the duration of the trial. CONCLUSIONS: The DD genotype may be associated with higher "weight sensitivity" in overweight white hypertensive persons, potentially through reduced activity of the renin-angiotensin and sympathetic systems after weight loss.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
William J Kostis; Javier Cabrera; W Craig Hooper; Paul K Whelton; Mark A Espeland; Nora M Cosgrove; Jerry Q Cheng; Yingzi Deng; Christine De Staerck; Meredith Pyle; et al.Hypertension 2013;61(4):857-63.
Jenny H Ledikwe; Barbara J Rolls; Helen Smiciklas-Wright; Diane C Mitchell; Jamy D Ard; Catherine Champagne; Njeri Karanja; Pao-Hwa Lin; Victor J Stevens; Lawrence J AppelThe American journal of clinical nutrition 2007;85(5):1212-21.
P K Whelton; L J Appel; M A Espeland; W B Applegate; W H Ettinger; J B Kostis; S Kumanyika; C R Lacy; K C Johnson; S Folmar; et al.
Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled trial of nonpharmacologic interventions in the elderly (TONE). TONE Collaborative Research Group.JAMA : the journal of the American Medical Association 1998;279(11):839-46.
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