Robert Black

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Supplementation with zinc, but not vitamin A, improves seroconversion to vibriocidal antibody in children given an oral cholera vaccine.

M John Albert; Firdausi Qadri; Mohammad A Wahed; Tanvir Ahmed; A S M Hamidur Rahman; Firoz Ahmed; Nurul A Bhuiyan; K Zaman; Abdullah H Baqui; John D Clemens; et al. (Profiled Authors: Abdullah Baqui; Robert Black)

International Centre for Diarrhoeal Disease Research, Bangladesh. john@hsc.kuniv.edu.kw
The Journal of infectious diseases 2003;187(6):909-13.

To investigate whether micronutrient supplementation could improve the vibriocidal antibody response of children to a killed oral cholera vaccine, 2-5-year-old children were randomly assigned to receive vitamin A and zinc (AZ group), vitamin A and a placebo (A group), zinc and a placebo (Z group), or both placebos (P group). All children received 2 doses of the vaccine. The number of children who had a > or = 4-fold increase in vibriocidal antibody was significantly greater in the AZ group than in the P group (P = .025-.028). Factorial analysis suggested that the proportion of children with a > or = 4-fold increase in vibriocidal antibody titer was significantly greater in the zinc-supplemented groups than in the groups that did not receive zinc (P = .013-.048) and that vitamin A supplementation did not have a significant effect. Thus, supplementation with zinc improves seroconversion to vibriocidal antibody and, hence, has the potential to improve the efficacy of oral cholera vaccine in children.

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