The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Mutational analysis of PINX1 in hereditary prostate cancer.
Gregory A Hawkins; Bao-Li Chang; S Lilly Zheng; Sarah D Isaacs; Kathleen E Wiley; Eugene R Bleecker; Patrick C Walsh; Deborah A Meyers; Jianfeng Xu; William B Isaacs (Profiled Authors: William Isaacs; Patrick Walsh)
Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
The Prostate 2004;60(4):298-302.
BACKGROUND: Telomerase activity is increased in most tumors. PinX1 has recently been identified as a critical component in regulating telomerase activity. The PinX1 gene is located within chromosomal region 8p22-23, a region associated with LOH and potentially linked to increased prostate cancer risk. METHODS: PINX1 was re-sequenced in 159 hereditary prostate cancer (HPC) probands. Four non-synonymous coding variants were genotyped in 159 HPC families. RESULTS: Thirty-nine polymorphisms were identified in the HPC screening panel. Ten coding polymorphisms were identified, seven (Gln50His, Leu91Met, Gln206His, Arg215Ile, Thr220Ala, Ser254Cys, and Glu414Ala) of which were non-synonymous. The most common variants Thr220Ala and Ser254Cys were not significantly over-transmitted from affected parent to affected offspring. CONCLUSIONS: Based on these results, we conclude that PINX1 is not a major factor for HPC risk.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Wennuan Liu; Chunmei Carol Xie; Yi Zhu; Tao Li; Jishan Sun; Yu Cheng; Charles M Ewing; Sue Dalrymple; Aubrey R Turner; Jielin Sun; et al.Neoplasia (New York, N.Y.) 2008;10(8):897-907.
J Xu; S L Zheng; G A Hawkins; D A Faith; B Kelly; S D Isaacs; K E Wiley; B Chang ; C M Ewing; P Bujnovszky; et al.American journal of human genetics 2001;69(2):341-50.
K Okami; L Wu; G Riggins; P Cairns; M Goggins; E Evron; N Halachmi; S A Ahrendt; A L Reed; W Hilgers; et al.Cancer research 1998;58(3):509-11.
Appears in this Publication
Author of this Publication