The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons.
Marjolein Visser; Bret H Goodpaster; Stephen B Kritchevsky; Anne B Newman; Michael Nevitt; Susan M Rubin; Eleanor M Simonsick; Tamara B Harris (Profiled Author: Eleanor Simonsick)
Institute for Research in Extramural Medicine, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands. firstname.lastname@example.org
The journals of gerontology. Series A, Biological sciences and medical sciences 2005;60(3):324-33.
BACKGROUND: Lower muscle mass has been correlated with poor physical function; however, no studies have examined this relationship prospectively. This study aims to investigate whether low muscle mass, low muscle strength, and greater fat infiltration into the muscle predict incident mobility limitation. METHODS: Our study cohort included 3075 well-functioning black and white men and women aged 70-79 years participating in the Health, Aging, and Body Composition study. Participants were followed for 2.5 years. Muscle cross-sectional area and muscle tissue attenuation (a measure of fat infiltration) were measured by computed tomography at the mid-thigh, and knee extensor strength by using a KinCom dynamometer. Incident mobility limitation was defined as two consecutive self-reports of any difficulty walking one-quarter mile or climbing 10 steps. RESULTS: Mobility limitations were developed by 22.3% of the men and by 31.8% of the women. Cox's proportional hazards models, adjusting for demographic, lifestyle, and health factors, showed a hazard ratio of 1.90 [95% confidence interval (CI), 1.27-2.84] in men and 1.68 (95% CI, 1.23-2.31) in women for the lowest compared to the highest quartile of muscle area (p <.01 for trend). Results for muscle strength were 2.02 (95% CI, 1.39-2.94) and 1.91 (95% CI, 1.41-2.58), p <.001 trend, and for muscle attenuation were 1.91 (95% CI, 1.31-2.83) and 1.68 (95% CI, 1.20-2.35), p <.01 for trend. When included in one model, only muscle attenuation and muscle strength independently predicted mobility limitation (p < .05). Among men and women, associations were similar for blacks and whites. CONCLUSION: Lower muscle mass (smaller cross-sectional thigh muscle area), greater fat infiltration into the muscle, and lower knee extensor muscle strength are associated with increased risk of mobility loss in older men and women. The association between low muscle mass and functional decline seems to be a function of underlying muscle strength.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Magdalena I Tolea; Luigi Ferrucci; Paul T Costa; Kimberly Faulkner; Caterina Rosano; Suzanne Satterfield; Hilsa N Ayonayon; Eleanor M Simonsick;The journals of gerontology. Series B, Psychological sciences and social sciences 2012;67(6):712-9.
Nathalie de Rekeneire; Marjolein Visser; Rita Peila; Michael C Nevitt; Jane A Cauley; Frances A Tylavsky; Eleanor M Simonsick; Tamara B HarrisJournal of the American Geriatrics Society 2003;51(6):841-6.
Daniel K White; Tuhina Neogi; Michael C Nevitt; Christine E Peloquin; Yanyan Zhu; Robert M Boudreau; Jane A Cauley; Luigi Ferrucci; Tamara B Harris; Susan M Satterfield; et al.The journals of gerontology. Series A, Biological sciences and medical sciences 2013;68(4):456-64.
Appears in this Publication
Author of this Publication