The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
What caused the epidemic of Pneumocystis pneumonia in European premature infants in the mid-20th century?
Armond S Goldman; Lynn R Goldman; Daniel A Goldman (Profiled Author: Lynn Goldman)
University of Texas Medical Branch, Galveston, TX 77555-0369, USA. firstname.lastname@example.org
An epidemic of interstitial pneumonia principally involving premature infants occurred in Germany and nearby European countries between the 1920s and 1960s. Fatalities were due to Pneumocystis. Because the principal defenses against Pneumocystis are T cells, an acquired T-cell deficiency was postulated. A number of potential causes including malnutrition were considered. All were implausible except for a retrovirus that was benign in adults but virulent in premature infants. Furthermore, we suspect that the virus was imported into Germany from former German African colonies. Premature infants were vulnerable because of the developmental status of their T cells. Given the practices in that part of Europe at that time, the virus was most likely transmitted by contaminated blood transfusions and subsequent contamination of reusable needles and syringes used in injections. Although the epidemic ended 4 decades ago, a search for the postulated retrovirus can be conducted if tissues from affected infants are available.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Nathan D Wolfe; William M Switzer; Jean K Carr; Vinod B Bhullar; Vedapuri Shanmugam; Ubald Tamoufe; A Tassy Prosser; Judith N Torimiro; Anthony Wright; Eitel Mpoudi-Ngole; et al.Lancet 2004;363(9413):932-7.
P M Pitha; D Biegel; R A Yetter; H C MorseJournal of immunology (Baltimore, Md. : 1950) 1988;141(10):3611-6.
E Frank; S H Weiss; J C Compas; J Bienstock; J Weber; A Bodner; S H LandesmanCancer research 1985;45(9 Suppl):4619s-4620s.
Appears in this Publication
Author of this Publication