The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
XTRPC1-dependent chemotropic guidance of neuronal growth cones.
Sangwoo Shim; Eyleen L Goh; Shaoyu Ge; Kurt Sailor; Joseph P Yuan; H Llewelyn Roderick; Martin D Bootman; Paul F Worley; Hongjun Song; Guo-li Ming (Profiled Authors: Paul Worley; Hongjun Song; Guo-Li Ming)
Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, Maryland 21205, USA.
Nature neuroscience 2005;8(6):730-5.
Calcium arising through release from intracellular stores and from influx across the plasma membrane is essential for signalling by specific guidance cues and by factors that inhibit axon regeneration. The mediators of calcium influx in these cases are largely unknown. Transient receptor potential channels (TRPCs) belong to a superfamily of Ca2+-permeable, receptor-operated channels that have important roles in sensing and responding to changes in the local environment. Here we report that XTRPC1, a Xenopus homolog of mammalian TRPC1, is required for proper growth cone turning responses of Xenopus spinal neurons to microscopic gradients of netrin-1, brain-derived neurotrophic factor and myelin-associated glycoprotein, but not to semaphorin 3A. Furthermore, XTRPC1 is required for midline guidance of axons of commissural interneurons in the developing Xenopus spinal cord. Thus, members of the TRPC family may serve as a key mediator for the Ca2+ influx that regulates axon guidance during development and inhibits axon regeneration in adulthood.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
G Ming; J Henley; M Tessier-Lavigne; H Song; M PooNeuron 2001;29(2):441-52.
Zhexing Wen; Liang Han; James R Bamburg; Sangwoo Shim; Guo-li Ming; James Q ZhengThe Journal of cell biology 2007;178(1):107-19.
Guo-li Ming; Scott T Wong; John Henley; Xiao-bing Yuan; Hong-jun Song; Nicholas C Spitzer; Mu-ming PooNature 2002;417(6887):411-8.
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