The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
The effects of vitamin C supplementation on serum concentrations of uric acid: results of a randomized controlled trial.
Han-Yao Huang; Lawrence J Appel; Michael J Choi; Allan C Gelber; Jeanne Charleston; Edward P Norkus; Edgar R Miller (Profiled Authors: Lawrence Appel; Edgar Miller; Michael Choi; Allan Gelber; Jeanne Charleston)
Johns Hopkins University, Baltimore, Maryland 21205, USA. firstname.lastname@example.org
Arthritis and rheumatism 2005;52(6):1843-7.
OBJECTIVE: Reductions in serum uric acid levels are clinically relevant. Previous studies have suggested a uricosuric effect of vitamin C. Whether vitamin C reduces serum uric acid is unknown. We undertook this study to determine the effects of vitamin C supplementation on serum uric acid concentrations. METHODS: The study was a double-blinded placebo-controlled randomized trial conducted in research units affiliated with an academic institution. Study participants were 184 nonsmokers, randomized to take either placebo or vitamin C supplements (500 mg/day) for 2 months. RESULTS: At the end of the study period, serum uric acid levels were significantly reduced in the vitamin C group (mean change -0.5 mg/dl [95% confidence interval -0.6, -0.3]), but not in the placebo group (mean change 0.09 mg/dl [95% confidence interval -0.05, 0.2]) (P < 0.0001). The same pattern of results was evident in subgroups defined by age, sex, race, body mass index, chronic illness, diuretic use, and quartiles of baseline serum ascorbic acid levels. In the subgroups, from the lowest to the highest quartile of baseline serum uric acid, net mean changes (95% confidence intervals) in serum uric acid with vitamin C supplementation were -0.4 (-0.8, 0.01), -0.5 (-0.9, -0.2), -0.5 (-0.8, -0.2), and -1.0 (-1.6, -0.4) mg/dl (P = 0.06, 0.005, 0.003, and 0.002, respectively). Compared with placebo, vitamin C increased the estimated glomerular filtration rate. CONCLUSION: Supplementation with 500 mg/day of vitamin C for 2 months reduces serum uric acid, suggesting that vitamin C might be beneficial in the prevention and management of gout and other urate-related diseases.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Stephen P Juraschek; Edgar R Miller; Allan C GelberArthritis care & research 2011;63(9):1295-306.
David D Waters; Edwin L Alderman; Judith Hsia; Barbara V Howard; Frederick R Cobb; William J Rogers; Pamela Ouyang; Paul Thompson; Jean Claude Tardif; Lyall Higginson; et al.JAMA : the journal of the American Medical Association 2002;288(19):2432-40.
Allan C GelberThe Journal of rheumatology 2008;35(9):1692-4.
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