The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Topical antisense oligonucleotide therapy against LIX, an enterocyte-expressed CXC chemokine, reduces murine colitis.
John H Kwon; Andrew C Keates; Pauline M Anton; Maria Botero; Jeffrey D Goldsmith; Ciarán P Kelly (Profiled Author: John Kwon)
Div. of Gastroenterology, Johns Hospikins University, Baltimore, MD, USA.
American journal of physiology. Gastrointestinal and liver physiology 2005;289(6):G1075-83.
Epithelial neutrophil-activating peptide-78 (ENA-78), a member of the CXC chemokine subfamily, is induced by inflammatory cytokines in human colonic enterocyte cell lines and increased in the colon of patients with inflammatory bowel disease (IBD). Lipopolysaccharide-induced CXC-chemokine (LIX) was recently identified as the murine homolog of ENA-78. Here we show that, similar to ENA-78, inflammatory cytokine stimulation of a murine colonic epithelial cell line, MODE-K, results in increased LIX expression. Consistent with the expression pattern of ENA-78 in IBD, LIX expression is significantly increased in mice with colitis induced by the ingestion of dextran sodium sulfate (DSS). Treating mice with antisense oligonucleotides to LIX via rectal enema delivery before DSS treatment results in colonic enterocyte uptake and a significant reduction in neutrophil infiltration and severity of colitis. These findings indicate that LIX plays an integral role in the pathogenesis of DSS-induced colitis. Similarly, enterocyte-derived CXC chemokines may play a key role in regulating neutrophil recruitment and intestinal injury in IBD. The intracolonic administration of ENA-78 antisense oligonucleotides may be effective in treating distal ulcerative colitis in humans.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
A C Keates; S Keates; J H Kwon; K O Arseneau; D J Law; L Bai; J L Merchant; T C Wang; C P KellyThe Journal of biological chemistry 2001;276(47):43713-22.
Feng Wu; Shukti ChakravartiJournal of immunology (Baltimore, Md. : 1950) 2007;179(10):6988-7000.
Mio Kawaguchi; Fumio Kokubu; Satoshi Matsukura; Koushi Ieki; Miho Odaka; Shin Watanabe; Shintaro Suzuki; Mitsuru Adachi; Shau-Ku Huang
Induction of C-X-C chemokines, growth-related oncogene alpha expression, and epithelial cell-derived neutrophil-activating protein-78 by ML-1 (interleukin-17F) involves activation of Raf1-mitogen-activated protein kinase kinase-extracellular signal-regulated kinase 1/2 pathway.The Journal of pharmacology and experimental therapeutics 2003;307(3):1213-20.
Appears in this Publication
Author of this Publication