The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Antibody-induced transplantation tolerance that is dependent on thymus-derived regulatory T cells.
Shaoping Deng; Daniel J Moore; Xiaolun Huang; Mohammad Mohiuddin; Major K Lee; Ergun Velidedeoglu; Moh-Moh Lian; Meredith Chiaccio; Samsher Sonawane; Anton Orlin; et al. (Profiled Author: H Ergun Velidedeoglu)
Harrison Department of Surgical Research, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):2799-807.
Targeting of the CD45RB isoform by mAb (anti-CD45RB) effectively induces donor-specific tolerance to allografts. The immunological mechanisms underlying the tolerant state remain unclear although some studies have suggested the involvement of regulatory T cells (T-regs). Although their generative pathway remains undefined, tolerance promoting T-regs induced by systemic anti-CD45RB treatment have been assumed to originate in the peripheral immune system. We demonstrate herein that separable effects on the peripheral and central immune compartments mediate graft survival induced by anti-CD45RB administration. In the absence of the thymus, anti-CD45RB therapy is not tolerogenic though it retains peripheral immunosuppressive activity. The thymus is required for anti-CD45RB to produce indefinite graft survival and donor-specific tolerance, and this effect is accomplished through thymic production of donor-specific T-regs. These data reveal for the first time an Ab-based tolerance regimen that relies on the central tolerance pathway.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Jose Trani; Daniel J Moore; Beth P Jarrett; Joseph W Markmann; Major K Lee; Andrew Singer; Moh-Moh Lian; Brian Tran; Andrew J Caton; James F MarkmannJournal of immunology (Baltimore, Md. : 1950) 2003;170(1):279-86.
L Chen; T Wang; P Zhou; L Ma; D Yin; J Shen; L Molinero; T Nozaki; T Phillips; S Uematsu; et al.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(10):2282-91.
E Velidedeoglu; B Jarret; K Lee; D Moore; X Huang; S Deng; M M Lian; A Caton; J F MarkmannTransplantation proceedings 2002;34(8):3342-4.
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