The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
A novel antiapoptotic role for alpha1-antitrypsin in the prevention of pulmonary emphysema.
Irina Petrache; Iwona Fijalkowska; Lijie Zhen; Terry R Medler; Emile Brown; Pedro Cruz; Kang-Hyeon Choe; Laimute Taraseviciene-Stewart; Robertas Scerbavicius; Lee Shapiro; et al. (Profiled Authors: Iwona Fijalkowska-Gorzka; Rubin Tuder)
Division of Pulmonary and Critical Care, Department of Medicine, John Hopkins University School of Medicine, Baltimore, Maryland, USA. email@example.com
American journal of respiratory and critical care medicine 2006;173(11):1222-8.
RATIONALE: There is growing evidence that alveolar cell apoptosis plays an important role in emphysema pathogenesis, a chronic inflammatory lung disease characterized by alveolar destruction. The association of alpha1-antitrypsin deficiency with the development of emphysema has supported the concept that protease/antiprotease imbalance mediates cigarette smoke-induced emphysema. OBJECTIVES: We propose that, in addition to its antielastolytic effects, alpha1-antitrypsin may have broader biological effects in the lung, preventing emphysema through inhibition of alveolar cells apoptosis. METHODS, MEASUREMENTS, AND MAIN RESULTS: Transduction of human alpha1-antitrypsin via replication-deficient adeno-associated virus attenuated airspace enlargement and emphysema caused by inhibition of vascular endothelial growth factor (VEGF) receptors with SU5416 in mice, a model of apoptosis-dependent emphysema lacking neutrophilic inflammation. The overexpressed human serine protease inhibitor accumulated in lung cells and suppressed caspase-3 activation and oxidative stress in lungs treated with the VEGF blocker or with VEGF receptor-1 and -2 antibodies. Similar results were obtained in SU5416-treated rats given human alpha1-antitrypsin intravenously. CONCLUSIONS: Our findings suggest that inhibition of structural alveolar cell apoptosis by alpha1-antitrypsin represents a novel protective mechanism of the serpin against emphysema. Further elucidation of this mechanism may extend the therapeutic options for emphysema caused by reduced level or loss of function of alpha1-antitrypsin.
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Rubin M Tuder; Lijie Zhen; Chung Y Cho; Laima Taraseviciene-Stewart; Yasunori Kasahara; Daniela Salvemini; Norbert F Voelkel; Sonia C FloresAmerican journal of respiratory cell and molecular biology 2003;29(1):88-97.
Laima Taraseviciene-Stewart; Ivor S Douglas; Patrick S Nana-Sinkam; Jong D Lee; Rubin M Tuder; Mark R Nicolls; Norbert F VoelkelProceedings of the American Thoracic Society 2006;3(8):687-90.
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