The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort.
Steven A Belinsky; Kieu C Liechty; Frederick D Gentry; Holly J Wolf; Justin Rogers; Kieu Vu; Jerry Haney; Tim C Kennedy; Fred R Hirsch; York Miller; et al. (Profiled Authors: James Herman; Stephen Baylin)
Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA. sbelinski@LRRI.org
Cancer research 2006;66(6):3338-44.
A sensitive screening approach for lung cancer could markedly reduce the high mortality rate for this disease. Previous studies have shown that methylation of gene promoters is present in exfoliated cells within sputum prior to lung cancer diagnosis. The purpose of the current study is to conduct a nested case-control study of incident lung cancer cases from an extremely high-risk cohort for evaluating promoter methylation of 14 genes in sputum. Controls (n = 92) were cohort members matched to cases (n = 98) by gender, age, and month of enrollment. The comparison of proximal sputum collected within 18 months to >18 months prior to diagnosis showed that the prevalence for methylation of gene promoters increased as the time to lung cancer diagnosis decreased. Six of 14 genes were associated with a >50% increased lung cancer risk. The concomitant methylation of three or more of these six genes was associated with a 6.5-fold increased risk and a sensitivity and specificity of 64%. This is the first study to prospectively examine a large panel of genes for their ability to predict lung cancer and shows the promise of gene promoter hypermethylation in sputum as a molecular marker for identifying people at high risk for cancer incidence.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Shuguang Leng; Kieu Do; Christin M Yingling; Maria A Picchi; Holly J Wolf; Timothy C Kennedy; William J Feser; Anna E Baron; Wilbur A Franklin; Malcolm V Brock; et al.Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(12):3387-95.
S A Belinsky; K J Nikula; W A Palmisano; R Michels; G Saccomanno; E Gabrielson; S B Baylin; J G HermanProceedings of the National Academy of Sciences of the United States of America 1998;95(20):11891-6.
Emi Ota Machida; Malcolm V Brock; Craig M Hooker; Jun Nakayama; Akiko Ishida; Jun Amano; Maria A Picchi; Steven A Belinsky; James G Herman; Shun'ichiro Taniguchi; et al.Cancer research 2006;66(12):6210-8.
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