The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
The benefit of upgrading chronically right ventricle-paced heart failure patients to resynchronization therapy demonstrated by strain rate imaging.
Zayd A Eldadah; Boaz Rosen; Ilan Hay; Thor Edvardsen; Vinod Jayam; Timm Dickfeld; Glenn R Meininger; Daniel P Judge; Joshua Hare; Joao B Lima; et al. (Profiled Authors: Joshua Hare; Joao Lima; Ronald Berger; Daniel Judge; Timm-Michael Dickfeld; Hugh Calkins; Zayd Eldadah)
Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA. email@example.com
Heart rhythm : the official journal of the Heart Rhythm Society 2006;3(4):435-42.
BACKGROUND: RV pacing induces conduction delay (CD), mechanical dyssynchrony, and increased morbidity in patients with HF. CRT improves HF symptoms and survival, but sparse data exist on its direct effect on chronically RV-paced HF patients. OBJECTIVES: To assess the benefit of cardiac resynchronization therapy (CRT) in chronically right ventricle (RV)-paced heart failure (HF) patients. METHODS: We studied 12 consecutive patients with class III HF who had a previously implanted pacemaker or implantable cardioverter-defibrillator. These individuals were chronically RV paced and referred for upgrade to a biventricular device by their primary cardiologists. Tissue Doppler and strain rate imaging (TDI and SRI, respectively) were performed immediately before each upgrade and 4-6 weeks afterward to quantify changes in regional wall motion and synchrony with CRT. RESULTS: CRT significantly reduced the mean QRS duration (205 ms to 156 ms; P<.0001), and it increased the ejection fraction (30.7%+/-5.1% to 35.8%+/-5.1%; P<.01). Left ventricular end-systolic and end-diastolic dimensions were also significantly reduced. Clinically, patients improved by an average of one New York Heart Association (NYHA) functional class after upgrade (P = .006). The parameter exhibiting greatest improvement was the coefficient of variation (CoV: standard deviation/mean) of time to peak systolic strain rate, a marker of ventricular dyssynchrony, which decreased from 34.3%+/-13.0% to 19.0%+/-6.6% (P<.01). Reduction in CoV of time to peak systolic strain rate was maximally seen in the midventricle (38.2%+/-19.6% to 16.5%+/-9.7%; P<.01). CONCLUSIONS: Upgrading chronically RV-paced HF patients to CRT improves global and regional systolic function. TDI and SRI provide compelling evidence that this benefit parallels that seen in HF patients with CD unrelated to RV pacing, which implies that biventricular pacing synchronizes mechanical activation in different myocardial regions in patients upgraded from RV pacing as well.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Theodore P Abraham; Niels Thue OlsenJACC. Cardiovascular imaging 2010;3(2):141-3.
David J Bradley; Elizabeth A Bradley; Kenneth L Baughman; Ronald D Berger; Hugh Calkins; Steven N Goodman; David A Kass; Neil R PoweJAMA : the journal of the American Medical Association 2003;289(6):730-40.
Frank B Sachse; Natalia S Torres; Eleonora Savio-Galimberti; Takeshi Aiba; David A Kass; Gordon F Tomaselli; John H BridgeCirculation research 2012;110(4):588-97.
Appears in this Publication
Author of this Publication