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Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cells.
Qi Cai; Natalia I Dmitrieva; Joan D Ferraris; Luis F Michea; Jesus M Salvador; M Christine Hollander; Albert J Fornace; Robert A Fenton; Maurice B Burg (Profiled Author: Maurice Burg)
Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1603, USA.
American journal of physiology. Renal physiology 2006;291(2):F341-9.
The response of renal inner medullary (IM) collecting duct cells (mIMCD3) to high NaCl involves increased expression of Gadd45 and p53, both of which have important effects on growth and survival of the cells. However, mIMCD3 cells, being immortalized by SV40, proliferate rapidly, which is known to sensitize cells to high NaCl, whereas IM cells in situ proliferate very slowly and survive much higher levels of NaCl. In the present studies, we have examined the importance of Gadd45 and p53 for survival of normal IM cells in their usual high-NaCl environment by using more slowly proliferating second-passage mouse inner medullary epithelial (p2mIME) cells and comparing cells from wild-type and gene knockout mice. Acutely elevating NaCl (and/or urea) reduces Gadd45a, but increases Gadd45b and Gadd45g mRNA, depending on the mix of NaCl and urea and the rate of increase of osmolality. Nevertheless, p2mIME cells from Gadd45b(-/-), Gadd45g(-/-), and Gadd45bg(-/-) mice survive elevation of NaCl (or urea) essentially the same as do wild-type cells. p53(-/-) Cells do not tolerate as high a concentration of NaCl (or urea) as p53(+/+) cells, but urinary concentrating ability of p53(-/-) mice is normal, as is the histology of inner medullas from p53(-/-) and Gadd45abg(-/-) mice. Thus although Gadd45 and p53 may play roles in osmotically stressed mIMCD3 cells, we do not find that their expression makes an important difference, either for Gadd45 in slower proliferating p2mIME cells or for Gadd45 or p53 in normal inner medullary epithelial cells in situ.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Devulapalli Chakravarty; Qi Cai; Joan D Ferraris; Luis Michea; Maurice B Burg; Dietmar KültzAmerican journal of physiology. Renal physiology 2002;283(5):F1020-9.
Zheng Zhang; Natalia I Dmitrieva; Jong-Hwan Park; Rodney L Levine; Maurice B BurgProceedings of the National Academy of Sciences of the United States of America 2004;101(25):9491-6.
Qi Cai; Natalia I Dmitrieva; Joan D Ferraris; Heddwen L Brooks; Bas W M van Balkom; Maurice BurgProceedings of the National Academy of Sciences of the United States of America 2005;102(2):503-8.
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