The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
A Staphylococcus aureus lipoteichoic acid (LTA) derived structural variant with two diacylglycerol residues.
A Stadelmaier; I Figueroa-Perez; S Deininger; S von Aulock; T Hartung; R R Schmidt (Profiled Author: Thomas Hartung)
Fachbereich Chemie, Universität Konstanz, Fach M 725, D-78457 Konstanz, Germany.
Bioorganic & medicinal chemistry 2006;14(18):6239-54.
Based on 1,2-O-isopropylidene-sn-glycerol five chiral building blocks containing differently modified glycerol residues were required for the synthesis of the target molecule 2. One of these building blocks is diacylglyceryl beta-gentiobioside carrying a phosphite residue at 6b-O position. Ligation of these five building blocks led to the desired glycerol phosphate backbone to which d-alanyl residues were attached, thus generating after O-deprotection the target molecule 2, a bisamphiphilic structural variant of Staphylococcus aureus LTA. This compound displayed higher potency in terms of cytokine release by human blood leukocytes than the monoamphiphilic variant LTA.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Susanne Deininger; Andreas Stadelmaier; Sonja von Aulock; Siegfried Morath; Richard R Schmidt; Thomas HartungJournal of immunology (Baltimore, Md. : 1950) 2003;170(8):4134-8.
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