The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
The role of an autoantigen, histidyl-tRNA synthetase, in the induction and maintenance of autoimmunity.
F W Miller; K A Waite; T Biswas; P H Plotz (Profiled Author: Paul Plotz)
Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9933-7.
Patients with systemic autoimmune diseases make specific autoantibodies that are directed against self structures. According to one view, these autoantibodies arise as a result of an immune response to foreign antigens such as infectious agents that share, by molecular mimicry, common structures with host proteins. An alternative view is that the target autoantigen itself initiates, selects, and sustains autoantibody synthesis. We show here that anti-Jo-1 autoantibodies directed against histidyl-tRNA synthetase in the human autoimmune muscle disease polymyositis undergo, in addition to spectrotype broadening and class switching, the sine qua non of an immune response to the target antigen--affinity maturation to that antigen. We demonstrate further that these autoantibodies, unlike anti-synthetase antibodies induced in mice immunized with heterologous antigen, bind only nonlinear epitopes on the native human synthetase that remain exposed when the enzyme is complexed to tRNA(His). These data suggest that the native target autoantigen itself has played a direct role in selecting and sustaining the autoantibody response and sharply restrict the time and the way in which a molecular mimic might act to provoke autoantibodies.
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T Biswas; F W Miller; Y Takagaki; P H PlotzJournal of immunological methods 1987;98(2):243-8.
N Raben; R Nichols; J Dohlman; P McPhie; V Sridhar; C Hyde; R Leff; P Plotz
A motif in human histidyl-tRNA synthetase which is shared among several aminoacyl-tRNA synthetases is a coiled-coil that is essential for enzymatic activity and contains the major autoantigenic epitope.The Journal of biological chemistry 1994;269(39):24277-83.
F W Miller; S A Twitty; T Biswas; P H PlotzThe Journal of clinical investigation 1990;85(2):468-75.
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