The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Plasma folate level, urinary arsenic methylation profiles, and urothelial carcinoma susceptibility.
Yung-Kai Huang; Yeong-Shiau Pu; Chi-Jung Chung; Horng-Sheng Shiue; Mo-Hsiung Yang; Chien-Jen Chen; Yu-Mei Hsueh (Profiled Author: Chi Chiung Grace Chen)
Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(3):929-38.
To elucidate the influence of folate concentration on the association between urinary arsenic profiles and urothelial carcinoma (UC) risks in subjects without evident arsenic exposure, 177 UC cases and 488 controls were recruited between September 2002 and May 2004. Urinary arsenic species including inorganic arsenic, monomethylarsonic acid (MMA(V)) and dimethylarsinic acid (DMA(V)) were determined by employing a high performance liquid chromatography-linked hydride generator and atomic absorption spectrometry procedure. After adjustment for suspected risk factors of UC, the higher indicators of urinary total arsenic levels, percentage of inorganic arsenic, percentage of MMA(V), and primary methylation index were associated with increased risk of UC. On the other hand, the higher plasma folate levels, urinary percentage of DMA(V) and secondary methylation index were associated with decreased risk of UC. A dose-response relationship was shown between plasma folate levels or methylation indices of arsenic species and UC risk in the respective quartile strata. The plasma folate was found to interact with urinary arsenic profiles in affecting the UC risk. The results of this study may identify the susceptible subpopulations and provide insight into the carcinogenic mechanisms of arsenic even at low arsenic exposure.
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Steven K Huang; Allen Wen-Hsiang Chiu; Yeong-Shiau Pu; Yung-Kai Huang; Chi-Jung Chung; Hui-Ju Tsai; Mo-Hsiung Yang; Chien-Jen Chen; Yu-Mei HsuehUrologia internationalis 2009;82(2):227-34.
Steven K Huang; Allen Wen-Hsiang Chiu; Yeong-Shiau Pu; Yung-Kai Huang; Chi-Jung Chung; Hui-Ju Tsai; Mo-Hsiung Yang; Chien-Jen Chen; Yu-Mei HsuehUrologia internationalis 2008;80(4):405-12.
Yeong-Shiau Pu; Shu-Mei Yang; Yung-Kai Huang; Chi-Jung Chung; Steven K Huang; Allen Wen-Hsiang Chiu; Mo-Hsiung Yang; Chien-Jen Chen; Yu-Mei HsuehToxicology and applied pharmacology 2007;218(2):99-106.
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