Neil Powe

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Cystatin C as a marker of cognitive function in elders: findings from the health ABC study.

Kristine Yaffe; Karla Lindquist; Michael G Shlipak; Eleanor Simonsick; Linda Fried; Caterina Rosano; Suzanne Satterfield; Hal Atkinson; B Gwen Windham; Manjula Kurella-Tamura (Profiled Author: Eleanor Simonsick)

Department of Psychiatry, School of Medicine, University of California, San Francisco, CA 94121, USA. kristine.yaffe@ucsf.edu
Annals of neurology 2008;63(6):798-802.

We determined whether serum cystatin C, a novel measure of kidney function that colocalizes with brain beta-amyloid, is associated with cognition among 3,030 elders. Those with high cystatin C (n = 445; 15%) had worse baseline scores on Modified Mini-Mental State Examination or Digit Symbol Substitution Test (p <or= 0.02) compared with those with intermediate/low level and 7 years greater decline (p <or= 0.04). Incident cognitive impairment (decline >or=1.0 standard deviation) was greatest among those with high cystatin C (Modified Mini-Mental State Examination: 38 vs 25%; adjusted odds ratio, 1.92; 95% confidence interval, 1.37-2.69; Digit Symbol Substitution: 38 vs 26%; odds ratio, 1.54; 95% confidence interval, 1.10-2.15).

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