The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Differential CMV-specific CD8+ effector T cell responses in the lung allograft predominate over the blood during human primary infection.
Matthew R Pipeling; Erin E West; Christine M Osborne; Amanda B Whitlock; Lesia K Dropulic; Matthew H Willett; Michael Forman; Alexandra Valsamakis; Jonathan B Orens; David R Moller; et al. (Profiled Authors: John Mcdyer; Jonathan Orens; David Moller; Noah Lechtzin; Alexandra Valsamakis)
Division of Pulmonary and Critical Care Medicine, Department of Pathology and Medical Microbiology, Johns Hopkins University, School of Medicine, Baltimore, MD 21224, USA.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(1):546-56.
Acquisition of T cell responses during primary CMV infection in lung transplant recipients (LTRs) appear critical for host defense and allograft durability, with increased mortality in donor+/recipient- (D+R-) individuals. In 15 D+R- LTRs studied, acute primary CMV infection was characterized by viremia in the presence or absence of pneumonitis, with viral loads higher in the lung airways/allograft compared with the blood. A striking influx of CD8+ T cells into the lung airways/allograft was observed, with inversion of the CD4+:CD8+ T cell ratio. De novo CMV-specific CD8+ effector frequencies in response to pooled peptides of pp65 were strikingly higher in lung mononuclear cells compared with the PBMC and predominated over IE1-specific responses and CD4+ effector responses in both compartments. The frequencies of pp65-specific cytokine responses were significantly higher in lung mononuclear cells compared with PBMC and demonstrated marked contraction with long-term persistence of effector memory CD8+ T cells in the lung airways following primary infection. CMV-tetramer+CD8+ T cells from PBMC were CD45RA- during viremia and transitioned to CD45RA+ following resolution. In contrast, CMV-specific CD8+ effectors in the lung airways/allograft maintained a CD45RA- phenotype during transition from acute into chronic infection. Together, these data reveal differential CMV-specific CD8+ effector frequencies, immunodominance, and polyfunctional cytokine responses predominating in the lung airways/allograft compared with the blood during acute primary infection. Moreover, we show intercompartmental phenotypic differences in CMV-specific memory responses during the transition to chronic infection.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Matthew R Pipeling; Emily R John; Jonathan B Orens; Noah Lechtzin; John F McDyerThe Journal of infectious diseases 2011;204(11):1663-71.
Oksana A Shlobin; Erin E West; Noah Lechtzin; Susan M Miller; Marvin Borja; Jonathan B Orens; Lesia K Dropulic; John F McDyerJournal of immunology (Baltimore, Md. : 1950) 2006;176(4):2625-34.
Ananta Paine; Mathias Oelke; Sabine Tischer; Hans-Gert Heuft; Rainer Blasczyk; Britta Eiz-VesperJournal of immunotherapy (Hagerstown, Md. : 1997) 2010;33(1):60-72.
Appears in this Publication
Author of this Publication