The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Nerve growth factor, nerve grafts and amniotic membrane grafts restore erectile function in rats.
J K Burgers; R J Nelson; D M Quinlan; P C Walsh (Profiled Author: Patrick Walsh)
James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland.
The Journal of urology 1991;146(2):463-8.
In an effort to reduce complications arising from radical pelvic surgery, an improved technique for restoration of autonomic innervation has been developed. The ability of nerve growth factor (NGF) alone or in combination with interposition nerve grafts, as well as the use of fetal amniotic membrane as an alternative growth matrix to enhance regeneration of ablated cavernous nerves were investigated in rats. Rats with ablated cavernous nerve displayed little or no penile erection, either in response to direct electrical stimulation or to an estrous female rat. A step wise improvement in electrically induced erections was observed by NGF alone, nerve graft alone, and the combination of NGF and nerve graft. Restoration of sexual behavior followed the same pattern obtained with electrical stimulation. Furthermore, the use of neonatal amniotic membrane as an alternative nerve growth matrix enhanced both electrically stimulated erection and mating behavior. These results suggest that the use of NGF and appropriate grafting materials can facilitate autonomic nerve regrowth and potentially reduce the morbidity of surgically induced nerve injuries.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Arthur L BurnettUrology 2003;61(3):491-7.
D M Quinlan; R J Nelson; P C WalshThe Journal of urology 1991;145(2):380-3.
Arthur L BurnettThe Journal of urology 2003;170(2 Pt 2):S31-4; discussion S34.
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