Hongjun Song

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Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain.

Regina L Faulkner; Mi-Hyeon Jang; Xiao-Bo Liu; Xin Duan; Kurt A Sailor; Ju Young Kim; Shaoyu Ge; Edward G Jones; Guo-li Ming; Hongjun Song; et al. (Profiled Authors: Hongjun Song; Guo-Li Ming)

Center for Neuroscience, University of California, Davis, CA 95618, USA.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(37):14157-62.

New neurons are continuously generated in restricted regions of the adult mammalian brain. Although these adult-born neurons have been shown to receive synaptic inputs, little is known about their synaptic outputs. Using retrovirus-mediated birth-dating and labeling in combination with serial section electron microscopic reconstruction, we report that mossy fiber en passant boutons of adult-born dentate granule cells form initial synaptic contacts with CA3 pyramidal cells within 2 weeks after their birth and reach morphologic maturity within 8 weeks in the adult hippocampus. Knockdown of Disrupted-in-Schizophrenia-1 (DISC1) in newborn granule cells leads to defects in axonal targeting and development of synaptic outputs in the adult brain. Together with previous reports of synaptic inputs, these results demonstrate that adult-born neurons are fully integrated into the existing neuronal circuitry. Our results also indicate a role for DISC1 in presynaptic development and may have implications for the etiology of schizophrenia and related mental disorders.

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