The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Surgical resection plus adjuvant radiotherapy is superior to surgery or radiotherapy alone in the prevention of neurological decline in a rat metastatic spinal tumor model.
Beril Gok; Matthew McGirt; Daniel M Sciubba; Selim Ayhan; Ali Bydon; Timothy F Witham; Jean-Paul Wolinsky; Ziya L Gokaslan (Profiled Authors: Daniel Sciubba; Jean-Paul Wolinsky; Ali Bydon; Timothy Witham; Hayriry Gok; Ziya Gokaslan)
Department of Neurosurgery, The Johns Hopkins University, Baltimore, Maryland, USA.
Neurosurgery 2008;63(2):346-51; discussion 351.
OBJECTIVE: The optimal management of spinal column metastatic disease is controversial. Furthermore, the literature lacks an accurate animal model to study the efficacy of surgical treatment options for spinal column metastases. We compared the efficacy of surgery, radiotherapy, or surgery plus adjuvant radiotherapy in a rat model of metastatic epidural spinal cord compression. METHODS: Thirty-two Fischer 344 rats underwent a transabdominal approach for implantation of a CRL-1666 breast adenocarcinoma cell line within the vertebral body of L6. Animals were randomly assigned to receive one of four treatments (n = 8 per group) 7 days after tumor implantation: 1) control: no treatment; 2) external beam radiation therapy (XRT) (total 20 Gy in 400-cGy daily fractions); 3) surgery: L6 vertebral corpectomy, tumor resection, and polymethyl methacrylate reconstruction; and 4) surgery + XRT: corpectomy and tumor resection followed by XRT (total 20 Gy in 400-cGy daily fractions) 72 hours after surgery. Hind-limb function was tested daily after treatment using the Basso-Beattie-Bresnahan (BBB) scale (range, 1-21). RESULTS: All animals (n = 32) demonstrated normal hind-limb function (BBB score, 21) on posttreatment Day 1. The XRT, surgery, and surgery + XRT groups all experienced a delay in onset of paresis versus the control group. Compared to the XRT group, the surgery group demonstrated greater median BBB scores on Days 3 (21 versus 20, P = 0.02) through 9 (12 versus 8, P = 0.002) after treatment. Compared with the surgery group, the surgery + XRT group demonstrated even greater median BBB scores on Days 6 (21 versus 19, P = 0.0008) through 11 (16 versus 8, P = 0.0001) after treatment. Median time to loss of ambulation (BBB <or= 7) was greatest in the surgery + XRT group (15 d) when compared with the surgery (12 d, P = 0.001), XRT (9 d, P = 0.001), or control groups (7 d, P = 0.0005). CONCLUSION: In a rat model of metastatic epidural spinal cord compression, decompressive surgery followed by radiotherapy yielded the greatest efficacy in the prevention of neurological decline when compared with surgery or radiotherapy alone. Radiotherapy alone attenuated neurological decline but was the least efficacious treatment in this model. These results support this animal model as an effective platform to investigate novel interventions for metastatic spine tumors.
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Beril Gok; Matthew J McGirt; Daniel M Sciubba; Giannina Garces-Ambrossi; Clarke Nelson; Joseph Noggle; Ali Bydon; Timothy F Witham; Jean-Paul Wolinsky; Ziya L GokaslanNeurosurgery 2009;65(1):193-9; discussion 199-200.
Matthew J McGirt; Beril Gok; Starane Shepherd; Joseph Noggle; Giannina L Garcés Ambrossi; Ali Bydon; Ziya L GokaslanJournal of neurosurgery. Spine 2009;10(1):9-15.
Justin Caplan; Gustavo Pradilla; Alia Hdeib; Betty M Tyler; Federico G Legnani; Carlos A Bagley; Henry Brem; George JalloNeurosurgery 2006;59(1):193-200; discussion 193-200.
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