The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Risk of mortality subsequent to umbilical cord infection among newborns of southern Nepal: cord infection and mortality.
Luke C Mullany; Gary L Darmstadt; Joanne Katz; Subarna K Khatry; Steven C Leclerq; Ramesh K Adhikari; James M Tielsch (Profiled Authors: Joanne Katz; James Tielsch; Subarna Khatry; Steven Leclerq; Luke Mullany)
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. firstname.lastname@example.org
The Pediatric infectious disease journal 2009;28(1):17-20.
BACKGROUND: Neonatal sepsis may stem from local umbilical cord infections. Signs of cord infection are common in low-resource settings, yet the risk of mortality subsequent to these signs has not been quantified in either developed or developing countries. We compared the risk of mortality between infants with and without signs of umbilical cord infection during a community-based trial of chlorhexidine interventions in southern Nepal. METHODS: Newborns were evaluated for signs of umbilical cord infection (pus, redness, swelling). A nested case-control approach was used to estimate the odds of mortality between infants with and without umbilical cord infection as defined by various levels of severity. For each death in the parent trial, 10 controls were selected, matched on sex, treatment group, and number of cord assessments. The main outcome measures were all-cause and sepsis-specific mortality. RESULTS: Among 23,246 assessed infants, there were 392 deaths. Odds of all-cause mortality were 46% (8-98%) higher among infants with redness extending onto the abdominal skin. A nonsignificant increased odds of mortality [odds ratio (OR): 2.31; 95% confidence interval (CI): 0.66-8.10] was observed among infants with severe redness and pus. Infections occurring after the third day of life were associated with subsequent risk of all-cause (OR: 3.11; 95% CI: 1.68-5.74) and sepsis-specific (OR: 4.63; 95% CI: 2.15-9.96) mortality. CONCLUSIONS: This study provides evidence that common local signs of cord infection are associated with increased risk of mortality. Where exposure of the umbilical cord to potentially invasive pathogens is high, interventions to increase hygienic care of the cord should be promoted and including hand washing, avoiding harmful topical applications, and topical cord antisepsis.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Luke C Mullany; Gary L Darmstadt; Joanne Katz; Subarna K Khatry; Steven C LeClerq; Ramesh K Adhikari; James M TielschAmerican journal of epidemiology 2007;165(2):203-11.
L C Mullany; G L Darmstadt; J Katz; S K Khatry; S C LeClerq; R K Adhikari; J M TielschArchives of disease in childhood. Fetal and neonatal edition 2006;91(2):F99-104.
Stephen Hodgins; Kusum Thapa; Leela Khanal; Shilu Aryal; Bal Krishna Suvedi; Urmilla Baidya; Luke C MullanyThe Pediatric infectious disease journal 2010;29(11):999-1003.
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