The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
In situ characterization of the degradation of PLGA microspheres in hyaluronic acid hydrogels by optical coherence tomography.
Jennifer Patterson; Patrick S Stayton; Xingde Li (Profiled Author: Xingde Li)
Department of Bioengineering, University of Washington, Seattle, WA 98195 USA. email@example.com
IEEE transactions on medical imaging 2009;28(1):74-81.
The polymeric implant material poly(lactide-co-glycolide) (PLGA) degrades by a process of bulk degradation, which allows it to be used for the controlled release of therapeutic molecules from implants and microspheres. The temporal characterization of PLGA microsphere degradation has been limited by the need to destructively monitor the samples at each time point. In this study, a noninvasive imaging technology, optical coherence tomography (OCT), was utilized to characterize the in situ degradation of PLGA microspheres suspended within photo-crosslinked hyaluronic acid (HA) hydrogels. Microspheres with differing degradation rates were loaded with bovine serum albumin (BSA) as a marker protein, and temporal release of protein was correlated with morphological changes observed during 3-D OCT imaging. As proof-of-principle, a microsphere-loaded hydrogel scaffold was implanted in a modified rat calvarial critical size defect model and imaged using OCT. This animal model presents the opportunity to monitor microsphere degradation over time in living animals.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Grace Y Kim; Betty M Tyler; Malinda M Tupper; Jeffrey M Karp; Robert S Langer; Henry Brem; Michael J CimaJournal of controlled release : official journal of the Controlled Release Society 2007;123(2):172-8.
Tara L Deans; Anirudha Singh; Matthew Gibson; Jennifer H ElisseeffProceedings of the National Academy of Sciences of the United States of America 2012;109(38):15217-22.
Yan Wang; Chao Wan; George Szöke; James T Ryaby; Gang LiJournal of orthopaedic research : official publication of the Orthopaedic Research Society 2008;26(4):539-46.
Appears in this Publication
Author of this Publication