The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
G-protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among African Americans: sex-specificity and interactions.
Vibha Bhatnagar; Daniel T O'Connor; Victoria H Brophy; Nicholas J Schork; Erin Richard; Rany M Salem; Caroline M Nievergelt; George L Bakris; John P Middleton; Keith C Norris; et al. (Profiled Author: Lawrence Appel)
Deparment of Family and Preventive Medicine, University of California San Diego, La Jolla, California, USA. firstname.lastname@example.org
American journal of hypertension 2009;22(3):332-8.
BACKGROUND: African Americans have a disproportionate burden of hypertension and comorbid disease. Pharmacogenetic markers of blood pressure response have yet to be defined clearly. This study explores the association between G-protein-coupled receptor kinase type 4 (GRK4) variants and blood pressure response to metoprolol among African Americans with early hypertensive nephrosclerosis. METHODS: Participants from the African American Study of Kidney Disease and Hypertension (AASK) trial were genotyped at three GRK4 polymorphisms: R65L, A142V, and A486V. A Cox proportional hazards model, stratified by gender, was used to determine the relationship between GRK4 variants and time to reach a mean arterial pressure (MAP) of 107 mm Hg, adjusted for other predictors of blood pressure response. Potential interactions between the three polymorphisms were explored by analyzing the effects of gene haplotypes and by stratifying the analysis by neighboring sites. RESULTS: The hazard ratio with 95% confidence interval by A142V among men randomized to a usual MAP (102-107 mm Hg) was 1.54 (1.11-2.44; P = 0.0009). The hazard ratio by A142V with R65/L65 or L65/L65 was 2.14 (1.35-3.39; P = 0.001). Haplotype analyses were consistent but inconclusive. There was no association between A142V and blood pressure response among women. CONCLUSIONS: Results suggest a sex-specific relationship between GRK4 A142V and blood pressure response among African-American men with early hypertensive nephrosclerosis. Men with a GRK4 A142 were less responsive to metoprolol if they had a GRK4 L65 variant. The effect of GRK4 variants and blood pressure response to metoprolol should be studied in larger clinical trials.
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L Y Agodoa; L Appel; G L Bakris; G Beck; J Bourgoignie; J P Briggs; J Charleston; D Cheek; W Cleveland; J G Douglas; et al.JAMA : the journal of the American Medical Association 2001;285(21):2719-28.
Keith Norris; Jacque Bourgoigne; Jennifer Gassman; Lee Hebert; John Middleton; Robert A Phillips; Otelio Randall; Stephen Rostand; Susan Sherer; Robert D Toto; et al.American journal of kidney diseases : the official journal of the National Kidney Foundation 2006;48(5):739-51.
Denyse Thornley-Brown; Xuelei Wang; Jackson T Wright; Otelio S Randall; Edgar R Miller; James P Lash; Jennifer Gassman; Gabriel Contreras; Lawrence J Appel; Lawrence Y Agodoa; et al.Archives of internal medicine 2006;166(7):797-805.
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