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Susan Folstein

Publication Detail

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The prevalence of fragile X in a sample of autistic individuals diagnosed using a standardized interview.

J Piven; J Gayle; R Landa; M Wzorek; S Folstein (Profiled Authors: Rebecca Landa; Susan Folstein)

Department of Psychiatry, University of Iowa Hospitals and Clinics.
Journal of the American Academy of Child and Adolescent Psychiatry 1991;30(5):825-30.

Abstract

The study examined 75 autistic individuals who met DSM-III-R criteria for autistic disorder at 5 years of age. Diagnosis was based on information elicited using a standardized interview for autism. Two of 75 (2.7%) autistic subjects expressed the fragile X marker (Xq27.3) in 40% of cells counted and had other affected family members. Two additional subjects expressed the fragile X anomaly at low rates (1%). These rates are compared with those reported in other studies. Methodological differences, which may underlie the varying rates reported across studies, are discussed.

Scientific Context

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