The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Cutting edge: SWI/SNF mediates antisense Igh transcription and locus-wide accessibility in B cell precursors.
Oleg A Osipovich; Ramesh Subrahmanyam; Steven Pierce; Ranjan Sen; Eugene M Oltz (Profiled Author: Ranjan Sen)
Department of Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232, USA.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):1509-13.
The stepwise process of Ag receptor gene assembly, termed V(D)J recombination, is coordinated during lymphocyte development by sweeping changes in chromatin that permit or deny access to a single recombinase enzyme. We now show that switching/sucrose nonfermenting (SWI/SNF) chromatin remodeling complexes are recruited to the Igh locus by an enhancer-dependent process and that these complexes are essential for generating recombinase accessibility throughout the locus. Depletion of SWI/SNF in pro-B cells also inhibits antisense transcription through all clusters of Igh gene segments, a pioneering process that has been implicated in the initial opening of chromatin. We conclude that SWI/SNF complexes play multiple roles in Igh gene assembly, ranging from initial locus activation to the spreading and maintenance of chromatin accessibility over large V(H), D(H), and J(H) domains.
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