Manuel Hidalgo

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Cutting edge: SWI/SNF mediates antisense Igh transcription and locus-wide accessibility in B cell precursors.

Oleg A Osipovich; Ramesh Subrahmanyam; Steven Pierce; Ranjan Sen; Eugene M Oltz (Profiled Author: Ranjan Sen)

Department of Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232, USA.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):1509-13.

The stepwise process of Ag receptor gene assembly, termed V(D)J recombination, is coordinated during lymphocyte development by sweeping changes in chromatin that permit or deny access to a single recombinase enzyme. We now show that switching/sucrose nonfermenting (SWI/SNF) chromatin remodeling complexes are recruited to the Igh locus by an enhancer-dependent process and that these complexes are essential for generating recombinase accessibility throughout the locus. Depletion of SWI/SNF in pro-B cells also inhibits antisense transcription through all clusters of Igh gene segments, a pioneering process that has been implicated in the initial opening of chromatin. We conclude that SWI/SNF complexes play multiple roles in Igh gene assembly, ranging from initial locus activation to the spreading and maintenance of chromatin accessibility over large V(H), D(H), and J(H) domains.

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