The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness.
Gerard H Koppelman; Deborah A Meyers; Timothy D Howard; S Lilly Zheng; Greg A Hawkins; Elizabeth J Ampleford; Jianfeng Xu; Henk Koning; Marcel Bruinenberg; Ilja M Nolte; et al. (Profiled Author: O'Colin Stine)
Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, P.O. Box 30001, 9700 RB Groningen, The Netherlands. email@example.com
American journal of respiratory and critical care medicine 2009;180(10):929-35.
RATIONALE: Asthma is a chronic inflammatory airway disease that affects more than 300 million individuals worldwide. Asthma is caused by interaction of genetic and environmental factors. Bronchial hyperresponsiveness (BHR) is a hallmark of asthma and results from increased sensitivity of the airways to physical or chemical stimulants. BHR and asthma are linked to chromosome 5q31-q33. OBJECTIVES: To identify a gene for BHR on chromosome 5q31-q33. METHODS: In 200 Dutch families with asthma, linkage analysis and fine mapping were performed, and the Protocadherin 1 gene (PCDH1) was identified. PCDH1 was resequenced in 96 subjects from ethnically diverse populations to identify novel sequence variants. Subsequent replication studies were undertaken in seven populations from The Netherlands, the United Kingdom, and the United States, including two general population samples, two family samples, and three case-control samples. PCDH1 mRNA and protein expression was investigated using polymerase chain reaction, Western blotting, and immunohistochemistry. MEASUREMENTS AND MAIN RESULTS: In seven out of eight populations (n = 6,168) from The Netherlands, United Kingdom, and United States, PCHD1 gene variants were significantly associated with BHR (P values, 0.005-0.05) This association was present in both families with asthma and general populations. PCDH1 mRNA and protein were expressed in airway epithelial cells and in macrophages. CONCLUSIONS: PCDH1 is a novel gene for BHR in adults and children. The identification of PCDH1 as a BHR susceptibility gene may suggest that a structural defect in the integrity of the airway epithelium, the first line of defense against inhaled substances, contributes to the development of BHR.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Deborah A Meyers; Dirkje S Postma; O Colin Stine; Gerard H Koppelman; Elizabeth J Ampleford; Hajo Jongepier; Timothy D Howard; Eugene R BleeckerThe Journal of allergy and clinical immunology 2005;115(6):1169-75.
C Lonjou; K Barnes; H Chen; W O Cookson; K A Deichmann; I P Hall; J W Holloway; T Laitinen; L J Palmer; M Wjst; et al.Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):10942-7.
Gerard H Koppelman; O Colin Stine; Jianfeng Xu; Timothy D Howard; Siqun L Zheng; Henk F Kauffman; Eugene R Bleecker; Deborah A Meyers; Dirkje S PostmaThe Journal of allergy and clinical immunology 2002;109(3):498-506.
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