The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Endothelial cell density to predict endothelial graft failure after penetrating keratoplasty.
Jonathan H Lass; Alan Sugar; Beth Ann Benetz; Roy W Beck; Mariya Dontchev; Robin L Gal; Craig Kollman; Robert Gross; Ellen Heck; Edward J Holland; et al. (Profiled Author: Walter Stark)
Department of Ophthalmology and Visual Sciences, Case Western Reserve University and University Hospitals Eye Institute, Cleveland, Ohio, USA. email@example.com
Archives of ophthalmology 2010;128(1):63-9.
OBJECTIVE: To determine whether preoperative and/or postoperative central endothelial cell density (ECD) and its rate of decline postoperatively are predictive of graft failure caused by endothelial decompensation following penetrating keratoplasty to treat a moderate-risk condition, principally, Fuchs dystrophy or pseudophakic corneal edema. METHODS: In a subset of Cornea Donor Study participants, a central reading center determined preoperative and postoperative ECD from available specular images for 17 grafts that failed because of endothelial decompensation and 483 grafts that did not fail. RESULTS: Preoperative ECD was not predictive of graft failure caused by endothelial decompensation (P = .91). However, the 6-month ECD was predictive of subsequent failure (P < .001). Among those that had not failed within the first 6 months, the 5-year cumulative incidence (+/-95% confidence interval) of failure was 13% (+/-12%) for the 33 participants with a 6-month ECD of less than 1700 cells/mm(2) vs 2% (+/-3%) for the 137 participants with a 6-month ECD of 2500 cells/mm(2) or higher. After 5 years' follow-up, 40 of 277 participants (14%) with a clear graft had an ECD below 500 cells/mm(2). CONCLUSIONS: Preoperative ECD is unrelated to graft failure from endothelial decompensation, whereas there is a strong correlation of ECD at 6 months with graft failure from endothelial decompensation. A graft can remain clear after 5 years even when the ECD is below 500 cells/mm(2).
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Bryan S Lee; Walter J Stark; Albert S JunClinical & experimental ophthalmology 2011;39(3):195-200.
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R Doyle Stulting; Alan Sugar; Roy Beck; Michael Belin; Mariya Dontchev; Robert S Feder; Robin L Gal; Edward J Holland; Craig Kollman; Mark J Mannis; et al.Cornea 2012;31(10):1141-7.
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