The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Photodynamic photorejuvenation of the face with a combination of microneedling, red light, and broadband pulsed light.
Matteo Tretti Clementoni; Marc B-Roscher; Girish S Munavalli (Profiled Author: Girish Munavalli)
Istituto Dermatologico Europeo, Plastic Surgery, Milan, Italy.
Lasers in surgery and medicine 2010;42(2):150-9.
BACKGROUND: High efficacy and safety, coupled with in-office, short contact protocols have made photodynamic therapy (PDT) with aminolevulenic acid (ALA) for the treatment of actinic keratoses a mainstay option over the last decade. Clinical improvement in photoaged skin has also been reported to accompany PDT treatments. The study objective was to maximize epidermal penetration and subsequent activation of ALA for the treatment of photodamaged facial skin, utilizing a microneedle roller prior to incubation and combined irradiation with red light and broadband pulsed light in a single treatment. MATERIALS AND METHODS: A full-face treatment of 21 patients was performed with 630 nm light and broadband pulsed light after multiple passes with a microneedle roller and 1-hour ALA incubation. The primary endpoint was clinical improvement, scored during two separate live assessments by three physicians blinded to previous scores, using a 5-point standardized photoaging scale. The secondary endpoint was evaluation of patient satisfaction based on a quartile scale comparing baseline to 6-month post-treatment photography. RESULTS: Statistically significant improvement was seen in the global photoaging scores, as well as sub-components of the scale (fine lines, mottled pigmentation, sallowness, tactile roughness, and telangiectasias) at 3 months as compared with baseline live assessment, and at 6-month live assessment compared with the 3 months. In addition, 90% of patients judged clinical improvement to be greater than 50% at 6 months compared to baseline photography. CONCLUSION: Use of a microneedle roller to "pre-treat" prior to application of ALA appears to be well tolerated and allows for even absorption and perhaps deeper penetration of ALA following a defined incubation period. Use of red light and broadband pulsed light allowed for deeper activation of ALA, potentially accounting for marked clinical improvement in photoaging.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Girish S Munavalli; Ayse Turley; Sirunya Silapunt; Brian BiesmanLasers in surgery and medicine 2011;43(4):273-82.
Jeffrey S Orringer; Craig Hammerberg; Ted Hamilton; Timothy M Johnson; Sewon Kang; Dana L Sachs; Gary Fisher; John J VoorheesArchives of dermatology 2008;144(10):1296-302.
Robert A Weiss; David H McDaniel; Roy G Geronemus; Margaret A Weiss; Karen L Beasley; Girish M Munavalli; Supriya G BellewDermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 2005;31(9 Pt 2):1199-205.
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