The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Thyroid hormone receptor beta mutation causes severe impairment of cerebellar development.
Aline Cristina Portella; Fernando Carvalho; Larissa Faustino; Fredric E Wondisford; Tânia Maria Ortiga-Carvalho; Flávia Carvalho Alcantara Gomes (Profiled Author: Fredric Wondisford)
Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, 21941-590, Rio de Janeiro, RJ, Brazil.
Molecular and cellular neurosciences 2010;44(1):68-77.
Cerebellar development on the postnatal period is mainly characterized by cellular proliferation in the external granular layer (EGL) followed by migration of granular cells in the molecular layer through the Bergmann glia (BG) fibers in order to form the granular layer in the adult. All these events are drastically affected by thyroid hormones (TH), which actions are mainly mediated by alpha (TRalpha) and beta (TRbeta) nuclear receptor isoforms. Here, we analyzed the effects of a natural human mutation (337T) in the TRbeta locus, which impairs T3 binding to its receptor, on the mouse cerebellum ontogenesis. We report that target inactivation of TRbeta-TH binding leads to a smaller cerebellum area characterized by impaired lamination and foliation. Further, TRbeta mutant mice presented severe deficits in proliferation of granular precursors, arborization of Purkinje cells and organization of BG fibers. Together, our data suggest that the action of TH via TRbeta regulates important events of cerebellar ontogenesis contributing to a better understanding of some neuroendocrine disorders. Further, our data correlate TRbeta with cerebellar foliation, and provide, for the first time, evidence of a receptor-mediated mechanism underlying TH actions on this event.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Anne-Lise Poguet; Claude Legrand; Xu Feng; Paul M Yen; Paul Meltzer; Jacques Samarut; Frédéric FlamantDevelopmental biology 2003;254(2):188-99.
Manuela Alonso; Charles Goodwin; Xiaohui Liao; Tania Ortiga-Carvalho; Danielle S Machado; Fredric E Wondisford; Samuel Refetoff; Roy E WeissEndocrinology 2009;150(8):3927-34.
Jing Wang; Ian C G Weaver; Andrée Gauthier-Fisher; Haoran Wang; Ling He; John Yeomans; Frederic Wondisford; David R Kaplan; Freda D MillerDevelopmental cell 2010;18(1):114-25.
Appears in this Publication
Author of this Publication