The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Up-regulation of striatal adenosine A(2A) receptors with iron deficiency in rats: effects on locomotion and cortico-striatal neurotransmission.
National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA. firstname.lastname@example.org
Experimental neurology 2010;224(1):292-8.
Brain iron deficiency leads to altered dopaminergic function in experimental animals, which can provide a mechanistic explanation for iron deficiency-related human sensory-motor disorders, such as Restless Legs Syndrome (RLS). However, mechanisms linking both conditions have not been determined. Considering the strong modulation exerted by adenosine on dopamine signaling, one connection could involve changes in adenosine receptor expression or function. In the striatum, presynaptic A(2A) receptors are localized in glutamatergic terminals contacting GABAergic dynorphinergic neurons and their function can be analyzed by the ability of A(2A) receptor antagonists to block the motor output induced by cortical electrical stimulation. Postsynaptic A(2A) receptors are localized in the dendritic field of GABAergic enkephalinergic neurons and their function can be analyzed by studying the ability of A(2A) receptor antagonists to produce locomotor activity and to counteract striatal ERK1/2 phosphorylation induced by cortical electrical stimulation. Increased density of striatal A(2A) receptors was found in rats fed during 3 weeks with an iron-deficient diet during the post-weaning period. In iron-deficient rats, the selective A(2A) receptor antagonist MSX-3, at doses of 1 and 3 mg/kg, was more effective at blocking motor output induced by cortical electrical stimulation (presynaptic A(2A) receptor-mediated effect) and at enhancing locomotor activation and blocking striatal ERK phosphorylation induced by cortical electrical stimulation (postsynaptic A(2A) receptor-mediated effects). These results indicate that brain iron deficiency induces a functional up-regulation of both striatal pre- and postsynaptic A(2A) receptor, which could be involved in sensory-motor disorders associated with iron deficiency such as RLS.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Zuzana Justinová; Sergi Ferré; Godfrey H Redhi; Paola Mascia; Jessica Stroik; Davide Quarta; Sevil Yasar; Christa E Müller; Rafael Franco; Steven R GoldbergAddiction biology 2011;16(3):405-15.
Seema Gulyani; Christopher J Earley; Simonetta Camandola; Stuart Maudsley; Sergi Ferré; Mohamed R Mughal; Bronwen Martin; Aiwu Cheng; Marc Gleichmann; Byron C Jones; et al.Experimental neurology 2009;215(2):236-42.
Raul Chavez-Valdez; Marsha Wills-Karp; Rajni Ahlawat; Elizabeth A Cristofalo; Amy Nathan; Estelle B GaudaPediatric research 2009;65(2):203-8.
Appears in this Publication
Author of this Publication