The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Insulin, leptin, and tumoral adipocytes promote murine pancreatic cancer growth.
Patrick B White; Eben M True; Kathryn M Ziegler; Sue S Wang; Deborah A Swartz-Basile; Henry A Pitt; Nicholas J Zyromski (Profiled Author: Henry Pitt)
Department of Surgery, Indiana University School of Medicine, 535 Barnhill Dr. RT 130, Indianapolis, IN 46202, USA. firstname.lastname@example.org
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2010;14(12):1888-93; discussion 1893-4.
BACKGROUND: Obesity accelerates development and growth of human pancreatic cancer. We recently reported similar findings in a novel murine model of pancreatic cancer in congenitally obese mice. The current experiments were designed to evaluate the effects of diet-induced obesity on pancreatic cancer growth. METHODS: Thirty C57BL/6J female mice were fed either control 10% fat (n = 10) or 60% fat diet (n = 20) starting at age 6 weeks. At 11 weeks, 2.5 × 10(5) PAN02 murine pancreatic cancer cells were inoculated. After 6 weeks, tumors were harvested. Serum adiponectin, leptin, insulin, and glucose concentrations were measured. Tumor proliferation, apoptosis, adipocyte content, and tumor-infiltrating lymphocytes were evaluated. RESULTS: The diet-induced obesity diet led to significant weight gain (control 21.3 ± 0.6 g; diet-induced obesity 23.1 ± 0.5 g; p = 0.03). Mice heavier than 23.1 g were considered "Overweight." Tumors grew significantly larger in overweight (1.3 ± 0.3 g) compared to lean (0.5 ± 0.2 g; p = 0.03) mice; tumor size correlated positively with body weight (R = 0.56; p < 0.02). Serum leptin (3.1 ± 0.7 vs. 1.4 ± 0.2 ng/ml) and insulin (0.5 ± 0.2 vs. 0.18 ± 0.02 ng/ml) were significantly greater in overweight mice. Tumor proliferation, apoptosis, and tumor adipocyte volume were similar. T and B lymphocytes were observed infiltrating tumors from lean and overweight mice in similar number. CONCLUSION: These data show that diet-induced obesity accelerates the growth of murine pancreatic cancer.
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Nicholas J Zyromski; Abhishek Mathur; Henry A Pitt; Terrence E Wade; Sue Wang; Poornima Nakshatri; Deborah A Swartz-Basile; Harikrishna NakshatriSurgery 2009;146(2):258-63.
Patrick B White; Kathryn M Ziegler; Deborah A Swartz-Basile; Sue S Wang; Keith D Lillemoe; Henry A Pitt; Nicholas J ZyromskiJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2012;16(9):1680-5.
Nicholas J Zyromski; Abhishek Mathur; Henry A Pitt; Debao Lu; John T Gripe; Julia J Walker; Kyle Yancey; Terence E Wade; Deborah A Swartz-BasileAmerican journal of physiology. Gastrointestinal and liver physiology 2008;295(3):G552-8.
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