The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Histamine H3 receptor agonists decrease hypothalamic histamine levels and increase stereotypical biting in mice challenged with methamphetamine.
Junichi Kitanaka; Nobue Kitanaka; F Scott Hall; George R Uhl; Tomohiro Tatsuta; Yoshio Morita; Koh-ichi Tanaka; Nobuyoshi Nishiyama; Motohiko Takemura (Profiled Author: George Uhl)
Department of Pharmacology, Hyogo College of Medicine, Hyogo 663-8501, Japan. firstname.lastname@example.org
Neurochemical research 2011;36(10):1824-33.
The effects of the histamine H(3) receptor agonists (R)-α-methylhistamine, imetit and immepip on methamphetamine (METH)-induced stereotypical behavior were examined in mice. The administration of METH (10 mg/kg, i.p.) to male ddY mice induced behaviors including persistent locomotion and stereotypical behaviors, which were classified into four categories: stereotypical head-bobbing (1.9%), circling (1.7%), sniffing (14.3%), and biting (82.1%). Pretreatment with (R)-α-methylhistamine (3 and 10 mg/kg, i.p.) significantly decreased stereotypical sniffing, but increased stereotypical biting induced by METH, in a dose-dependent manner. This effect of (R)-α-methylhistamine on behavior was mimicked by imetit or immepip (brain-penetrating selective histamine H(3) receptor agonists; 10 mg/kg, i.p. for each drug). Hypothalamic histamine levels 1 h after METH challenge were significantly increased in mice pretreated with saline. These increases in histamine levels were significantly decreased by pretreatment with histamine H(3) receptor agonists, effects which would appear to underlie the shift from METH-induced stereotypical sniffing to biting.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
J Kitanaka; N Kitanaka; T Tatsuta; F S Hall; G R Uhl; K Tanaka; N Nishiyama; Y Morita; M TakemuraPsychopharmacology 2009;203(4):781-92.
T Tsukamoto; M Iyo; K Tani; Y Sekine; K Hashimoto; Y Ohashi; K Suzuki; Y Iwata; N MoriPsychopharmacology 2001;158(2):107-13.
H C Champion; P J KadowitzEuropean journal of pharmacology 1998;343(2-3):209-16.
Appears in this Publication
Author of this Publication