The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Estimated net endogenous acid production and serum bicarbonate in African Americans with chronic kidney disease.
Julia J Scialla; Lawrence J Appel; Brad C Astor; Edgar R Miller; Srinivasan Beddhu; Mark Woodward; Rulan S Parekh; Cheryl A M Anderson (Profiled Authors: Mark Woodward; Julia Scialla; Rulan Parekh; Lawrence Appel; Edgar Miller; Brad Astor; Cheryl Anderson)
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA. email@example.com
Clinical journal of the American Society of Nephrology : CJASN 2011;6(7):1526-32.
BACKGROUND AND OBJECTIVES: Metabolic acidosis may contribute to morbidity and disease progression in patients with chronic kidney disease (CKD). The ratio of dietary protein, the major source of nonvolatile acid, to dietary potassium, which is naturally bound to alkali precursors, can be used to estimate net endogenous acid production (NEAP). We tested the association between estimated NEAP and serum bicarbonate in patients with CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: NEAP was estimated among 462 African American adults with hypertensive CKD using published equations: NEAP (mEq/d) = -10.2 + 54.5 (protein [g/d]/potassium [mEq/d]). Dietary protein and potassium intake were estimated from 24-hour urinary excretion of urea nitrogen and potassium, respectively. All of the eligible measurements during follow-up were modeled using generalized linear regression clustered by participant and adjusted for demographics, 24-hour urinary sodium, kidney function, and selected medications. RESULTS: Higher NEAP was associated with lower serum bicarbonate in a graded fashion (P trend < 0.001). Serum bicarbonate was 1.27 mEq/L lower among those in the highest compared with the lowest quartile of NEAP (P < 0.001). There was a greater difference in serum bicarbonate between the highest and lowest quartiles of NEAP among patients with stage 4/5 CKD (-2.43 mEq/L, P < 0.001) compared with those with stage 2/3 disease (-0.77 mEq/L, P = 0.01; P-interaction = 0.02). CONCLUSIONS: Reducing NEAP, through reduction of dietary protein and increased intake of fruits and vegetables, may prevent metabolic acidosis in patients with CKD.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
L Frassetto; R C Morris; D E Sellmeyer; K Todd; A SebastianEuropean journal of nutrition 2001;40(5):200-13.
Craig S Wong; Christopher B Pierce; Stephen R Cole; Bradley A Warady; Robert H K Mak; Nadine M Benador; Fredrick Kaskel; Susan L Furth; George J Schwartz;Clinical journal of the American Society of Nephrology : CJASN 2009;4(4):812-9.
Michael J Fischer; Paul L Kimmel; Tom Greene; Jennifer J Gassman; Xuelei Wang; Deborah H Brooks; Jeanne Charleston; Donna Dowie; Denyse Thornley-Brown; Lisa A Cooper; et al.Kidney international 2010;77(11):1010-9.
Appears in this Publication
Author of this Publication