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Michael Choti

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Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma.

Meng Li; Hong Zhao; Xiaosong Zhang; Laura D Wood; Robert A Anders; Michael A Choti; Timothy M Pawlik; Hubert D Daniel; Rajesh Kannangai; G Johan A Offerhaus; et al. (Profiled Authors: Nickolas Papadopoulos; Robert Anders; Ralph Hruban; Kenneth Kinzler; Michael Choti; Shibin Zhou; Timothy Pawlik; G. Offerhaus; Victor Velculescu; Michael Torbenson; Bert Vogelstein)

Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nature genetics 2011;43(9):828-9.

Abstract

Through exomic sequencing of ten hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected individuals, we discovered novel inactivating mutations of ARID2 in four major subtypes of HCC (HCV-associated HCC, hepatitis B virus (HBV)-associated HCC, alcohol-associated HCC and HCC with no known etiology). Notably, 18.2% of individuals with HCV-associated HCC in the United States and Europe harbored ARID2 inactivation mutations, suggesting that ARID2 is a tumor suppressor gene that is relatively commonly mutated in this tumor subtype.

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