The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma.
Meng Li; Hong Zhao; Xiaosong Zhang; Laura D Wood; Robert A Anders; Michael A Choti; Timothy M Pawlik; Hubert D Daniel; Rajesh Kannangai; G Johan A Offerhaus; et al. (Profiled Authors: Nickolas Papadopoulos; Robert Anders; Ralph Hruban; Kenneth Kinzler; Michael Choti; Shibin Zhou; Timothy Pawlik; G. Offerhaus; Victor Velculescu; Michael Torbenson; Bert Vogelstein)
Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nature genetics 2011;43(9):828-9.
Through exomic sequencing of ten hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected individuals, we discovered novel inactivating mutations of ARID2 in four major subtypes of HCC (HCV-associated HCC, hepatitis B virus (HBV)-associated HCC, alcohol-associated HCC and HCC with no known etiology). Notably, 18.2% of individuals with HCV-associated HCC in the United States and Europe harbored ARID2 inactivation mutations, suggesting that ARID2 is a tumor suppressor gene that is relatively commonly mutated in this tumor subtype.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
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