The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Lysophosphatidic acid increases soluble ST2 expression in mouse lung and human bronchial epithelial cells.
Jing Zhao; Qingyuan Chen; Hong Li; Michael Myerburg; Ernst Wm Spannhake; Viswanathan Natarajan; Yutong Zhao (Profiled Author: Ernst Spannhake)
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Cellular signalling 2012;24(1):77-85.
Lysophosphatidic acid (LPA), a naturally occurring bioactive lysophospholipid increases the expression of both pro-inflammatory and anti-inflammatory mediators in airway epithelial cells. Soluble ST2 (sST2), an anti-inflammatory mediator, has been known to function as a decoy receptor of interleukin (IL)-33 and attenuates endotoxin-induced inflammatory responses. Here, we show that LPA increased sST2 mRNA expression and protein release in a dose and time dependent manner in human bronchial epithelial cells (HBEpCs). LPA receptors antagonist and Gαi inhibitor, pertussis toxin, attenuated LPA-induced sST2 release. Inhibition of NF-κB or JNK pathway reduced LPA-induced sST2 release. LPA treatment decreased histone deacetylase 3 (HDAC3) expression and enhanced acetylation of histone H3 at lysine 9 that binds to the sST2 promoter region. Furthermore, limitation of intracellular LPA generation by the down-regulation of acetyl glycerol kinase attenuated exogenous LPA-induced histone H3 acetylation on sST2 promoter region, as well as sST2 gene expression. Treatment of HBEpCs with recombinant sST2 protein or sST2-rich cell culture media attenuated endotoxin-induced phosphorylation of PKC and airway epithelial barrier disruption. These results unravel a novel sST2 mediated signaling pathway that has physiological relevance to airway inflammation and remodeling.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Bahman Saatian; Yutong Zhao; Donghong He; Steve N Georas; Tonya Watkins; Ernst Wm Spannhake; Viswanathan NatarajanThe Biochemical journal 2006;393(Pt 3):657-68.
Donghong He; Viswanathan Natarajan; Randi Stern; Irina A Gorshkova; Julian Solway; Ernst Wm Spannhake; Yutong Zhao
Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E(2) release via C/EBPbeta in human bronchial epithelial cells.The Biochemical journal 2008;412(1):153-62.
Jing Wang; Ian C G Weaver; Andrée Gauthier-Fisher; Haoran Wang; Ling He; John Yeomans; Frederic Wondisford; David R Kaplan; Freda D MillerDevelopmental cell 2010;18(1):114-25.
Appears in this Publication
Author of this Publication