The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Comparison of humoral immune responses to Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus using a viral proteome microarray.
Dasheng Zheng; Jun Wan; Yong Gu Cho; Leyao Wang; Chuang-Jiun Chiou; Shweta Pai; Crystal Woodard; Jian Zhu; Gangling Liao; Otoniel Martinez-Maza; et al. (Profiled Authors: S Hayward; Chuang-Jiun Chiou; Gary Hayward; Gangling Liao; Heng Zhu; Richard Ambinder; Jiang Qian)
Viral Oncology Program, Sidney Kimmel Cancer Center, Baltimore, Maryland, USA.
The Journal of infectious diseases 2011;204(11):1683-91.
BACKGROUND: Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, and Kaposi's sarcoma-associated herpesvirus (KSHV) has a restricted seroprevalence. Both viruses are associated with malignancies that have an increased frequency in individuals who are coinfected with human immunodeficiency virus type 1 (HIV-1). METHODS: To obtain an overview of humoral immune responses to these viruses, we generated a protein array that displayed 174 EBV and KSHV polypeptides purified from yeast. Antibody responses to EBV and KSHV were examined in plasma from healthy volunteers and patients with B cell lymphoma or with AIDS-related Kaposi's sarcoma or lymphoma. RESULTS: In addition to the commonly studied antigens, IgG responses were frequently detected to the tegument proteins KSHV ORF38 and EBV BBRF and BGLF2 and BNRF1 and to the EBV early lytic proteins BRRF1 and BORF2. The EBV vIL-10 protein was particularly well recognized by plasma IgA. The most intense IgG responses to EBV antigens occurred in HIV-1-positive patients. No clear correlation was observed between viral DNA load in plasma and antibody profile. CONCLUSIONS: The protein array provided a sensitive platform for global screening; identified new, frequently recognized viral antigens; and revealed a broader humoral response to EBV compared with KSHV in the same patients.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Q J Wang; F J Jenkins; L P Jacobson; Y X Meng; P E Pellett; L A Kingsley; K G Kousoulas; A Baghian; C R RinaldoThe Journal of infectious diseases 2000;182(3):928-32.
Eric Nawar; Sam M Mbulaiteye; Joel E Gallant; David A Wohl; Marianne Ardini; Tabitha Hendershot; James J Goedert; Charles S Rabkin;International journal of cancer. Journal international du cancer 2005;115(2):296-300.
Richard F AmbinderHematology/oncology clinics of North America 2003;17(3):697-702, v-vi.
Appears in this Publication
Author of this Publication