The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Stress responses affecting homeostasis of the alveolar capillary unit.
Rubin M Tuder; Toshinori Yoshida (Profiled Author: Rubin Tuder)
Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA. Rubin.Tuder@ucdenver.edu
Proceedings of the American Thoracic Society 2011;8(6):485-91.
The maintenance of the alveolar structure is required throughout life. To accomplish this goal, alveolar cells, including endothelial, epithelial, and fibroblastic cells, provide key molecules with broad survival and antiapoptotic effects. These complex interactions are disrupted by cigarette smoke, leading to emphysema. Smoke imposes an environmental stress to the lung with the activation of "sensor-like" molecular signaling. Activation of RTP801, leading to mTOR inhibition, is paradigmatic of these responses. The accumulation of cellular damage, with the generation of endogenous mediators of inflammation, may proceed toward an aging phenotype. These alterations may impose significant challenges to cell-based regenerative or pharmacological therapies.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
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Toshinori Yoshida; Igor Mett; Anil K Bhunia; Joel Bowman; Mario Perez; Li Zhang; Aneta Gandjeva; Lijie Zhen; Ugonma Chukwueke; Tianzhi Mao; et al.Nature medicine 2010;16(7):767-73.
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