The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Pneumococcal sequence type replacement among American Indian children: a comparison of pre- and routine-PCV7 eras.
Jennifer R Scott; William P Hanage; Marc Lipsitch; Eugene V Millar; Lawrence H Moulton; Jason Hinds; Raymond Reid; Mathuram Santosham; Katherine L O'Brien (Profiled Authors: Raymond Reid; Katherine O'Brien; Lawrence Moulton; Eugene Millar; Mathuram Santosham)
Center for American Indian Health, Department of International Health, Johns Hopkins Bloomberg School of Public Health, 621N. Washington Street, Baltimore, MD 21205, United States.
BACKGROUND: Multi-locus sequence typing (MLST) of pneumococcal isolates collected during an efficacy trial of the 7-valent pneumococcal conjugate vaccine (PCV7) among Navajo and White Mountain Apache children from 1998 to 2000 showed a non-differential expansion of pre-existing sequence types (STs) and only one capsule-switching event in the PCV7-randomized communities. PCV7 was introduced as a routine infant vaccine in October 2000. We assessed variability in PCV7 effectiveness and mechanisms of ST replacement after prolonged routine PCV7 use. METHODS: We applied MLST to 267 non-vaccine type pneumococcal carriage and invasive disease isolates from Navajo and White Mountain Apache children from 2006 to 2008, and compared them to those from 1998 to 2000. Microarray was used to confirm capsule switching events. RESULTS: The primary mechanism of ST replacement among Navajo and White Mountain Apache children was expansion of existing STs, although introduction of new STs was an important secondary mechanism. ST199, a majority being serotype 19A, was the most common ST in both eras. Only ST193 (serotype 21) was preferentially expanding in the PCV7 era. Three examples of capsule switching were identified. No variability in vaccine effectiveness by ST was observed. CONCLUSION: We did not observe an influence of ST on PCV7 serotype-specific effectiveness, although some STs may be favored in replacement.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Marc Lipsitch; Keith O'Neill; Derrick Cordy; Boris Bugalter; Krzysztof Trzcinski; Claudette M Thompson; Richard Goldstein; Stephen Pelton; Heather Huot; Valerie Bouchet; et al.The Journal of infectious diseases 2007;196(8):1221-7.
Katherine L O'Brien; Jana Shaw; Robert Weatherholtz; Raymond Reid; James Watt; Janne Croll; Ron Dagan; Alan J Parkinson; Mathuram SantoshamAmerican journal of epidemiology 2004;160(3):270-8.
Katherine L O'Brien; Eugene V Millar; Elizabeth R Zell; Melinda Bronsdon; Robert Weatherholtz; Raymond Reid; Jocelyn Becenti; Sheri Kvamme; Cynthia G Whitney; Mathuram SantoshamThe Journal of infectious diseases 2007;196(8):1211-20.
Appears in this Publication
Author of this Publication