The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Epigenetics in ovarian cancer.
L M S Seeber; P J van Diest (Profiled Author: Paulus Van Diest)
Department of Reproductive Medicine and Gynaecology, Gynaecological Oncology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Methods in molecular biology (Clifton, N.J.) 2012;863():253-69.
Ovarian cancer is the most lethal gynecological cancer. Due to few early symptoms and a lack of early detection strategies, most patients are diagnosed with advanced-stage disease. Most of these patients, although initially responsive, eventually develop drug resistance. In this chapter, epigenetic changes in ovarian cancer are described. Various epigenetic changes including CpG island methylation and histone modification have been identified in ovarian cancer. These aberrations are associated with distinct disease subtypes and present in circulating serum of ovarian cancer patients. Several epigenetic changes have shown promise for their diagnostic, prognostic, and predictive capacity but still need further validation.In contrast to DNA mutations and deletions, epigenetic modifications are potentially reversible by epigenetic therapies. Promising preclinical studies show epigenetic drugs to enhance gene re-expression and drug sensitivity in ovarian cancer cell lines and animal models.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Yan Jia; Mingzhou GuoChinese journal of cancer 2013;32(1):21-30.
Jianming Ying; Zifen Gao; Hongyu Li; Gopesh Srivastava; Paul G Murray; Hwee Koon Goh; Chai Yen Lim; Yajun Wang; Teresa Marafioti; David Y Mason; et al.British journal of haematology 2007;136(6):829-32.
Michael T McCabe; Johann C Brandes; Paula M VertinoClinical cancer research : an official journal of the American Association for Cancer Research 2009;15(12):3927-37.
Appears in this Publication
Author of this Publication