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Genetic basis for species vulnerability in the cheetah.
S J O'Brien; M E Roelke; L Marker; A Newman; C A Winkler; D Meltzer; L Colly; J F Evermann; M Bush; D E Wildt (Profiled Author: R. Bush)
Science (New York, N.Y.) 1985;227(4693):1428-34.Abstract
A population genetic survey of over 200 structural loci previously revealed that the South African cheetah (Acinonyx jubatus jubatus) has an extreme paucity of genetic variability, probably as a consequence of a severe population bottleneck in its recent past. The genetic monomorphism of the species is here extended to the major histocompatibility complex, since 14 reciprocal skin grafts between unrelated cheetahs were accepted. The apparent consequences of such genetic uniformity to the species include (i) great difficulty in captive breeding, (ii) a high degree of juvenile mortality in captivity and in the wild, and (iii) a high frequency of spermatozoal abnormalities in ejaculates. The species vulnerability of the cheetah was demonstrated by an epizootic of coronavirus-associated feline infectious peritonitis in an Oregon breeding colony in 1983. Exposure and spread of the coronavirus, which has a very low morbidity in domestic cats (approximately 1 percent), has decimated a heretofore productive and healthy captive population. The extreme genetic monomorphism, especially at the major histocompatibility complex, and the apparent hypersensitivity of the cheetah to a viral pathogen may be related, and provide a biological basis for understanding the adaptive significance of abundant genetic variation in outbred mammalian species.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
J L Heeney; J F Evermann; A J McKeirnan; L Marker-Kraus; M E Roelke; M Bush; D E Wildt; D G Meltzer; L Colly; J LukasJournal of virology 1990;64(5):1964-72.
D E Wildt; S J O'Brien; J G Howard; T M Caro; M E Roelke; J L Brown; M BushBiology of reproduction 1987;36(2):351-60.
S J O'Brien; D E Wildt; M Bush; T M Caro; C FitzGibbon; I Aggundey; R E LeakeyProceedings of the National Academy of Sciences of the United States of America 1987;84(2):508-11.
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