The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Treatment of congenital osteopetrosis with high-dose calcitriol.
L Key; D Carnes; S Cole; M Holtrop; Z Bar-Shavit; F Shapiro; R Arceci; J Steinberg; C Gundberg; A Kahn (Profiled Author: Robert Arceci)
The New England journal of medicine 1984;310(7):409-15.Abstract
We administered high doses of calcitriol (up to 32 micrograms per day) to an infant with malignant osteopetrosis, in an attempt to stimulate bone resorption. The patient was placed on a low-calcium diet to prevent hypercalcemia. Measures of bone turnover increased during calcitriol therapy; hydroxyproline excretion rose from 140 to 1358 micrograms per milligram of creatinine per 24 hours, with parallel increases in the ratio of calcium to creatinine in the urine, urinary gamma-carboxyglutamic acid, serum osteocalcin, and serum alkaline phosphatase. A pretreatment bone-biopsy specimen contained no osteoclasts with ruffled borders, a feature of active osteoclasts. After 11 days of calcitriol, ruffled borders were noted. After three months, numerous osteoclasts with ruffled borders and associated bony disruption were evident. Before therapy, the patient's monocytes were incapable of in vitro bone resorption, but after calcitriol, their resorptive capacity was increased to 3.3 times control levels. These data demonstrate that calcitriol increased bone mineral and matrix turnover in our patient. However, during the three months of calcitriol therapy there was only slight clinical improvement in her severe disease. Early and sustained treatment with calcitriol may be useful in osteopetrosis.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
T Cundy; J A Kanis; G Heynen; M Earnshaw; T L Clemens; J L O'Riordan; A L Merrett; J E CompstonBritish medical journal (Clinical research ed.) 1982;284(6319):883-5.
T P Jacobs; A C Gordon; S J Silverberg; E Shane; L Reich; T L Clemens; C M GundbergThe American journal of medicine 1987;82(2A):42-50.
F R Singer; T L Clemens; R A Eusebio; P J BekkerThe Journal of clinical endocrinology and metabolism 1998;83(6):1906-10.
Appears in this Publication
Author of this Publication