The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Effect of potassium supplementation on blood pressure in African Americans on a low-potassium diet. A randomized, double-blind, placebo-controlled trial.
Welch Center for Prevention, Epidemiology, & Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Md., USA.
Archives of internal medicine 1996;156(1):61-7.
OBJECTIVE: To determine the effect of potassium supplementation on blood pressure in African Americans consuming a low-potassium diet. DESIGN: Randomized, double-blind, placebo-controlled trial with two parallel arms. SETTING: Community-based research site. PARTICIPANTS: Eighty-seven healthy African Americans aged 27 to 65 years with a systolic blood pressure between 100 and 159 mm Hg and a diastolic blood pressure between 70 and 94 mm Hg. INTERVENTION: During the 21-day intervention period, all participants were provided with a low-potassium diet (32 to 35 mmol/d). In addition to this diet, they were randomly assigned to receive either potassium supplements (80 mmol/d) or placebo. MAIN OUTCOME MEASURE: Change in blood pressure in the potassium vs the placebo group, based on a total of nine blood pressure readings at three visits. Blood pressures were taken before and during the intervention by means of random-zero sphygmomanometry. RESULTS: At baseline, the placebo and potassium groups were similar for mean blood pressure (127/78 vs 125/77 mm Hg), 24-hour urinary potassium excretion (50 vs 44 mmol), and all other variables measured (all P > .05). During the intervention, the net difference in 24-hour urinary potassium excretion between groups was 70 mmol. Compared with the placebo group, the potassium supplementation group experienced a net decline in systolic blood pressure of 6.9 mm Hg (95% confidence interval, -9.3 to -4.4 mm Hg; P < .001) and a decline in diastolic blood pressure of 2.5 mm Hg (95% confidence interval, -4.3 to -0.8 mm Hg; P = .004). Simultaneous adjustment for differences in baseline characteristics only strengthened these estimates. CONCLUSIONS: Potassium supplementation reduces blood pressure substantially in African Americans consuming a diet low in potassium. Increased potassium intake may play an important role in reducing blood pressure in this population at high risk for hypertension.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
F M Sacks; L E Brown; L Appel; N O Borhani; D Evans; P WheltonHypertension 1995;26(6 Pt 1):950-6.
Sunil Sazawal; Usha Dhingra; Pratibha Dhingra; Girish Hiremath; Jitendra Kumar; Archana Sarkar; Venugopal P Menon; Robert E BlackBMJ (Clinical research ed.) 2007;334(7585):140.
R M Bostick; L Fosdick; J R Wood; P Grambsch; G A Grandits; T J Lillemoe; T A Louis; J D PotterJournal of the National Cancer Institute 1995;87(17):1307-15.
Appears in this Publication
Author of this Publication