The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Dopamine transporters decrease with age.
N D Volkow; Y S Ding; J S Fowler; G J Wang; J Logan; S J Gatley; R Hitzemann; G Smith; S D Fields; R Gur (Profiled Author: Gwenn Smith)
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1996;37(4):554-9.
UNLABELLED: Postmortem studies have documented degeneration of dopamine cells with age, but the changes that occur in healthy aging individuals is less clear. The purpose of this study was to evaluate the extent to which age-induced changes in dopamine transporters occur in subjects with no evidence of motor impairment. METHODS: We evaluated 23 right-handed healthy volunteers (age range 20-74 yr) using PET and [11C]d-threo-methylphenidate. The ratio of the distribution volume for [11C]d-threo-methylphenidate in striatum to that in cerebellum was used as model parameter for dopamine transporter availability (Bmax/Kd + 1). RESULTS: Dopamine transporter availability was significantly lower in subjects > 40 yr of age than in those < 40 yr. Estimates of dopamine transporter availability showed a significant negative correlation with age both for the putamen (r = -0.72, p < 0.0001) and the caudate (r = -0.74, p < 0.0001). Dopamine transporter availability was higher in the left than in the right putamen but did not differ between the left and right caudate. CONCLUSION: This study documents a 6.6% decrease per decade of life in striatal dopamine transporters of healthy volunteers.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
U D McCann; D F Wong; F Yokoi; V Villemagne; R F Dannals; G A RicaurteThe Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(20):8417-22.
Pedro Rosa Neto; Hans Lou; Paul Cumming; Ole Pryds; Albert GjeddeAnnals of the New York Academy of Sciences 2002;965():434-9.
D F Wong; J C Harris; S Naidu; F Yokoi; S Marenco; R F Dannals; H T Ravert; M Yaster; A Evans; O Rousset; et al.Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5539-43.
Appears in this Publication
Author of this Publication