The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Abrogation of cell-mediated immunity by a serum blocking factor isolated from patients with infectious mononucleosis.
W H Wainwright; R W Veltri; P M Sprinkle (Profiled Author: Robert Veltri)
The Journal of infectious diseases 1979;140(1):22-32.Abstract
Lymphocytes from 80% of patients with infectious mononucleosis in this study failed to produce macrophage migration-inhibition factor in response to partially purified early antigen of Epstein-Barr virus or to tetanus toxoid, whereas lymphocytes from normal subjects did produce this lymphokine. Subsequent analysis of serum from the patients with infectious mononucleosis revealed a serum factor that completely abrogated antigen-specific inhibition of migration by human leukocytes as well as lymphocyte blastogenesis. The serum blocking factor was present in sera from 11 (73%) of 15 patients with infectious mononucleos but only in sera from two (13%) of 15 normal subjects. Samples of serum from five of the patients with infectious mononucleosis and five normal subjects were fractionated with use of Sephadex G-200 gel filtration, and the eluants were assayed for several substances known to inhibit cell-mediated immunity. Serum blocking factor activity could be demonstrated only in fractionated sera from patients with infectious mononucleosis. The serum blocking factor is postulated to be either a soluble immune complex or some as yet unidentified immunoregulatory globulin contained in the IgG fraction of human serum.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
S C Schimpff; J E BennettThe Journal of allergy and clinical immunology 1975;55(6):430-41.
R W Veltri; J E McClung; P M SprinkleInternational journal of cancer. Journal international du cancer 1978;21(6):683-7.
R W Veltri; S M Rodman; P E Maxim; M W Baseler; P M SprinkleCancer 1986;57(12):2295-308.
Appears in this Publication
Author of this Publication